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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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Catalog Number Size Price
LS-C154960-100 100 µg (0.5 mg/ml) $405 
GRN / Granulin Antibody - GRN antibody (1 ug/ml) staining of A431 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Polyclonal Goat anti‑Human GRN / Granulin Antibody (aa248‑259, WB) LS‑C154960

Polyclonal Goat anti‑Human GRN / Granulin Antibody (aa248‑259, WB) LS‑C154960

Antibody:
Goat Polyclonal to Human GRN / Granulin
Application:
WB, Peptide-ELISA
Reactivity:
Human, Monkey, Mouse, Rat, Hamster
Format:
Unconjugated, Unmodified
Price
Catalog Number
$405 
LS-C154960-100
100 µg
0.5 mg/ml
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Goat Polyclonal to Human GRN / Granulin
Application:
WB, Peptide-ELISA
Reactivity:
Human, Monkey, Mouse, Rat, Hamster
Format:
Unconjugated, Unmodified

Specifications

Description
Granulin antibody LS-C154960 is an unconjugated goat polyclonal antibody to Granulin (GRN) (aa248-259) from human. It is reactive with human, mouse, rat and other species. Validated for Peptide-ELISA and WB. Cited in 1 publication.
Target
Human GRN / Granulin
Synonyms
GRN | Acrogranin | CLN11 | Epithelin precursor | GEP | gp88 | Granulin | Granulin-epithelin | Granulins | PC cell-derived growth factor | PCDGF | PEPI | PGRN | Proepithelin | Progranulin
Host
Goat
Reactivity
Human, Monkey, Mouse, Rat, Hamster (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Modifications
Unmodified
Applications
  • Western blot (1 - 3 µg/ml)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:8000)
Immunogen
Peptide with sequence PQDTVCDLIQSK, from the internal of the protein sequence according to NP_002078.1.
Blocking Peptide
LS-E27830 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C154960. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa248-259
Specificity
Human GRN / Granulin. This antibody is expected to recognize the C-Terminal part of Granulin-3.
Usage
Peptide ELISA: antibody detection limit dilution 1:8000. Western blot: Approx 75kD band observed in lysates of cell lines A431, A549 and HeLa (calculated MW of 63.5kD according to NP_002078.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (He and Bateman, Cancer Res. 1999 Jul 1;59(13):3222-9. PMID: 10397269). Recommended concentration: 1-3 ug/ml.
Presentation
TBS, pH 7.3, 0.02% Sodium Azide, 0.5% BSA
Storage
Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About GRN / Granulin
P28799 NM_002087 NP_002078.1

LSBio Ratings

GRN / Granulin Antibody (aa248-259) for WB/Western LS-C154960 has an LSBio Rating of
Publications (4)

Publications (1)

Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations. Holler CJ, Taylor G, Deng Q, Kukar T. eNeuro. 2017 August;4:

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Requested From: United States
Date Requested: 7/13/2020