GRK5

G protein-coupled receptor kinase 5

Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).

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Products

Antibodies (45)

Proteins (6)

ELISA Kits (3)

Type

Cell-Based (1)

Custom (1)

Over-Expression Lysate (2)

Primary (45)

Recombinant (4)

Sandwich (1)

Target

GRK5 (54)

Reactivity

Human (47)

Mouse (28)

Rat (16)

Bat (5)

Bovine (11)

Chicken (8)

Chimpanzee (6)

Dog (7)

Gibbon (6)

Guinea pig (6)

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Orangutan (6)

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IHC (18)

IHC-P (10)

WB (36)

ELISA (12)

IF (1)

IP (1)

Peptide-ELISA (2)

Host

rabbit (44)

mouse (1)

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IHCPlus (5)

Isotype

IgG (23)

IgG2a,k (1)

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monoclonal mc (1)

polyclonal pc (44)

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96-Well Microplate (2)

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Epitope

aa304-532 (8)

aa559-590 (7)

aa290-339 (4)

aa369-418 (4)

Internal (3)

N-Terminus (2)

320-400 aa, Internal (1)

Gln382 (1)

aa351-400 (1)

aa393-429 (1)

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No (54)

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Adherent Cell Cultures (1)

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Tissue Homogenates (1)

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Low endotoxin level (1)

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IHC-plus™ GRK5 Antibody LS-B1813

(4.0) Rating

Antibody:

GRK5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Chicken, Zebrafish, Pufferfish, Bovine, Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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GRK5 Antibody (Internal) LS-C352276

Antibody:

GRK5 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$299

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IHC-plus™ GRK5 Antibody (Internal) LS-A3030

Fast Shipping

(4.0) Rating

Antibody:

GRK5 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ GRK5 Antibody (N-Terminus) LS-A3470

Fast Shipping

(4.0) Rating

Antibody:

GRK5 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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GRK5 Antibody LS-C670188

Antibody:

GRK5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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IHC-plus™ GRK5 Antibody (Internal) LS-A3034

Fast Shipping

(4.0) Rating

Antibody:

GRK5 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

Select

IHC-plus™ GRK5 Antibody (N-Terminus) LS-A3400

Fast Shipping

(4.0) Rating

Antibody:

GRK5 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Dog, Bovine, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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GRK5 Antibody LS-C490383

Antibody:

GRK5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

Select

GRK5 Antibody (aa393-429) LS-C407920

Antibody:

GRK5 Rabbit anti-Human Polyclonal (aa393-429) Antibody

Reactivity:

Mouse, Bovine, Pig, Bat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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GRK5 Antibody LS-C804500

Antibody:

GRK5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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GRK5 Antibody (aa559-590) LS-C98905

Antibody:

GRK5 Rabbit anti-Human Polyclonal (aa559-590) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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GRK5 Antibody (aa559-590) LS-C327491

Antibody:

GRK5 Rabbit anti-Human Polyclonal (aa559-590) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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GRK5 Antibody (aa559-590, Biotin) LS-C219652

Antibody:

GRK5 Rabbit anti-Human Polyclonal (aa559-590) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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GRK5 Antibody (aa559-590, FITC) LS-C219653

Antibody:

GRK5 Rabbit anti-Human Polyclonal (aa559-590) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

GRK5 Antibody (aa559-590, APC) LS-C219651

Antibody:

GRK5 Rabbit anti-Human Polyclonal (aa559-590) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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GRK5 Antibody (aa559-590, Azide-free, HRP) LS-C219654

Antibody:

GRK5 Rabbit anti-Human Polyclonal (aa559-590) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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GRK5 Antibody (aa559-590, PE) LS-C219656

Antibody:

GRK5 Rabbit anti-Human Polyclonal (aa559-590) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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GRK5 Antibody (320-400 aa, Internal) LS-C383865

Antibody:

GRK5 Rabbit anti-Human Polyclonal (320-400 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

GRK5 Antibody (Gln382) LS-C176749

Antibody:

GRK5 Rabbit anti-Human Polyclonal (Gln382) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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GRK5 Antibody LS-C665995

Antibody:

GRK5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

GRK5 Antibody LS-C822701

Antibody:

GRK5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

GRK5 Antibody (aa351-400) LS-C118866

Antibody:

GRK5 Rabbit anti-Human Polyclonal (aa351-400) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

GRK5 Antibody (clone 1D9) LS-C197338

Antibody:

GRK5 Mouse anti-Human Monoclonal (1D9) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µg/$423

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GRK5 Antibody (Preservative Free) LS-C818036

Antibody:

GRK5 Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

Select

GRK5 Antibody LS-C767016

Antibody:

GRK5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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