Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
GRIK1 / GLUR5 antibody was raised against kLH-conjugated, synthetic peptide corresponding to amino acids 937–949 (CHQRRTQRKETVA) of rat GluR5–2C isoform precursor. This sequence is identical in rat isoforms GluR5–2 and GluR5–2B/GluR5–1 and human GluR5 isoform 2/EAA3A, and is not present in rat isoform GluR5–2A and human GluR5 isoform 1.
Recognizes GluR5 isoforms, Mr 105-110kD. Species cross-reactivity: Rat. Predicted to cross-react with certain human and mouse GluR5 isoforms, based on sequence homology.
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.