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GPX4 / MCSP
glutathione peroxidase 4
GPX4 / MCSP is a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants.
| Gene Name: | glutathione peroxidase 4 |
| Synonyms: | GPX4, GPx-4, MCSP, SnPHGPx, Phospholipid hydroperoxidase, SnGPx, Glutathione peroxidase 4, GSHPx-4, PHGPx |
| Target Sequences: | NM_002085 NP_002076.2 P36969 |
Publications (6)
1
SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. Papp LV, Lu J, Bolderson E, Boucher D, Singh R, Holmgren A, Khanna KK. Antioxidants & redox signaling. 2010 12:797-808. (WB)
[PubMed:19803747]
Related Antibodies: LS-B3246.
2
Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. Schoenmakers E, Agostini M, Mitchell C, Schoenmakers N, Papp L, Rajanayagam O, Padidela R, Ceron-Gutierrez L, Doffinger R, Prevosto C, Luan J, Montano S, Lu J, Castanet M, Clemons N, Groeneveld M, Castets P, Karbaschi M, Aitken S, Dixon A, Williams J, Cam. The Journal of clinical investigation. 2010 120:4220-35.
[PubMed:21084748]
[PMC:PMC2993594]
Related Antibodies: LS-B3246.
3
Epidermal Cells Expressing Putative Cell Markers in Nonglabrous Skin Existing in Direct Proximity with the Distal End of the Arrector Pili Muscle. Torkamani N, Rufaut NW, Jones L, Sinclair R. Stem cells international. 2016 2016:1286315. (IHC; Mouse)
[Full Text Article]
[PubMed:27375744]
[PMC:PMC4916308]
Related Antibodies: LS-B1596.
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GPX4 / MCSP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
GPX4 / MCSP Goat anti-Human Polyclonal (aa184-196) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
GPX4 / MCSP Rabbit anti-Human Polyclonal (aa81-93) Antibody
Chicken, Bovine, Mouse, Goat, Dog, Guinea pig, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
1 Each/$485
GPX4 / MCSP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
GPX4 / MCSP Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
E. coli
His-T7
18.1 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
GPX4 / MCSP Rabbit anti-Human Polyclonal (aa74-197) Antibody
Mouse, Human
ICC, IP, WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
Development Kit
Antibody Pair and Standard
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,276; 1000 Wells/$1,903
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 405nm (ABTS)
Plasma
1 Plate/$783
E. coli
His-GST
46.2 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
GPX4 / MCSP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
GPX4 / MCSP Rabbit anti-Mouse Polyclonal Antibody
Mouse, Guinea pig, Rat
ELISA, WB
Unconjugated
100 µg/$567
GPX4 / MCSP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GPX4 / MCSP Rabbit anti-Human Polyclonal (aa72-121) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
GPX4 / MCSP Rabbit anti-Human Polyclonal (aa72-121) (HRP) Antibody
Zebrafish, Rat, Mouse, Goat, Guinea pig, Bovine, Human, Monkey, Orangutan, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
GPX4 / MCSP Rabbit anti-Human Polyclonal (aa72-121) (Biotin) Antibody
Zebrafish, Rat, Mouse, Goat, Guinea pig, Bovine, Human, Monkey, Orangutan, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
GPX4 / MCSP Rabbit anti-Human Polyclonal (aa72-121) (FITC) Antibody
Zebrafish, Rat, Mouse, Goat, Guinea pig, Bovine, Human, Monkey, Orangutan, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
GPX4 / MCSP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
GPX4 / MCSP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$834
GPX4 / MCSP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
GPX4 / MCSP Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
GPX4 / MCSP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
GPX4 / MCSP Mouse anti-Human Monoclonal (565320) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$856
GPX4 / MCSP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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