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| Catalog Number | Size | Price |
|---|---|---|
| LS-A168-50 | 50 µg (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human GPR6 Antibody (Cytoplasmic Domain, IHC) LS‑A168
PathPlus™ Polyclonal Rabbit anti‑Human GPR6 Antibody (Cytoplasmic Domain, IHC) LS‑A168
Antibody:
GPR6 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Pig, Rabbit
Format:
Unconjugated, Unmodified
Overview
Antibody:
GPR6 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Pig, Rabbit
Format:
Unconjugated, Unmodified
Specifications
Description
G protein-coupled receptor 6 (GPR6) is a transmembrane receptor with constitutive G(s) signaling activity that upregulates cyclic AMP. GPR6 promotes neurite outgrowth and blocks myelin inhibition in neurons. In immunohistochemsitry, GPR6 expression is limited to the nervous system, and it has membranous positivity primarily in the basal ganglia, with variable positivity in the cerebral cortex, amygdala, thalamus, hippocampus and pituitary gland.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human GPR6
Synonyms
GPR6 | G protein-coupled receptor 6 | G-protein coupled receptor 6 | RCNL3
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Pig, Rabbit
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 15 amino acid peptide from 3rd cytoplasmic domain of human GPR6. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Dog, Bat, Hamster, Elephant, Rabbit, Pig (100%); Opossum (80%).
Epitope
Cytoplasmic Domain
Specificity
Human GPR6. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR12 (60%).
Applications
- IHC
- IHC - Paraffin (6 - 9 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GPR6
Validation
Brain, Thalamus, neurons
Brain, Thalamus, neurons
Brain, Medulla, Hypoglossal nucleus
Brain, Medulla, Hypoglossal nucleus
Anti-GPR6 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR6 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ GPR6 Antibody (Cytoplasmic Domain) for IHC LS-A168 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Reactivity:
Human
Range:
0.41-100 ng/ml
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/19/2024
Date Requested: 4/19/2024
