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GPR49 / LGR5

leucine-rich repeat containing G protein-coupled receptor 5

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Gene Name:	leucine-rich repeat containing G protein-coupled receptor 5
Family/Subfamily:	GPCR , Orphan-A
Synonyms:	LGR5, FEX, G-protein coupled receptor 49, G protein-coupled receptor 49, GPR67, GRP49, GPR49, HG38, G-protein coupled receptor 67
Target Sequences:	NM_003667 NP_003658.1 O75473

Publications (12)

Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer. Kleist B, Xu L, Li G, Kersten C. International journal of clinical and experimental pathology. 2011 4:327-35. (IHC-P; Human) [Full Text Article] [PubMed:21577318] [PMC:PMC3093057] Related Antibodies: LS-A1236.

EP receptor expression in human intestinal epithelium and localization relative to the stem cell zone of the crypts. Olsen Hult LT, Kleiveland CR, Fosnes K, Jacobsen M, Lea T. PloS one. 2011 6:e26816. (ICC, IHC-P; Human) [Full Text Article] [PubMed:22046368] [PMC:PMC3201980] Related Antibodies: LS-A1236, LS-A1232.

Prognostic impact of mRNA levels of LGR5 transcript variants in OSCC patients. Rot S, Kaune T, Taubert H, Greither T, Kotrba J, Güttler A, Wichmann H, Bilkenroth U, Wienke A, Al-Nawas B, Bache M, Vordermark D, Wickenhauser C, Bethmann D, Eckert AW, Kappler M. BMC cancer. 2019 February;19:155. [Full Text Article] [PubMed:30770730] [PMC:PMC6377725]

CD133 expression predicts post-operative recurrence in patients with colon cancer with peritoneal metastasis. Nagata H, Ishihara S, Kishikawa J, Sonoda H, Murono K, Emoto S, Kaneko M, Sasaki K, Otani K, Nishikawa T, Tanaka T, Kiyomatsu T, Hata K, Kawai K, Nozawa H. International journal of oncology. 2018 March;52:721-732. [Full Text Article] [PubMed:29328371] [PMC:PMC5807045]

LGR5 expression in oral epithelial dysplasia and oral squamous cell carcinoma. Andrew J Dalley, Ahmad A Abdul Majeed, Luke P Pitty, Aidan G Major, Camile S Farah. Oral surgery, oral medicine, oral pathology, oral radiology. 2015 April;119:436-40.e1. [Full Text Article] [PubMed:25592865]

Lgr5 over-expression is positively related to the tumor progression and HER2 expression in stage pTNM IV colorectal cancer. Feng-Juan Gao, Jie-Yu Chen, Hong-Yan Wu, Jiong Shi, Ming Chen, Xiang-Shan Fan, Qin Huang. International journal of clinical and experimental pathology. 2014 May;7:1572-9. [Full Text Article] [PubMed:24817953] [PMC:PMC4014237]

Cell hierarchy and lineage commitment in the bovine mammary gland. Gat Rauner, Itamar Barash. PloS one. 2012 January;7:e30113. [Full Text Article] [PubMed:22253899] [PMC:PMC3258259]

LGR5 expression predicts peritoneal recurrence after curative resection of primary colon cancer. Hiroshi Nagata, Soichiro Ishihara, Hiroyuki Abe, Tetsuo Ushiku, Junko Kishikawa, Toshiaki Tanaka, Keisuke Hata, Kazushige Kawai, Masashi Fukayama, Hiroaki Nozawa. British journal of cancer. 2019 May;120:996-1002. [Full Text Article] [PubMed:31000786] [PMC:PMC6734652] Related Antibodies: LS-A1232.

Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses. Chen QQ, Yan L, Wang CZ, Wang WH, Shi H, Su BB, Zeng QH, Du HT, Wan J. World journal of gastroenterology : WJG. 2013 Aug;19:4702-17. [Full Text Article] [PubMed:23922467] [PMC:PMC3732842] Related Antibodies: LS-A1236.

LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells. Nakata S, Campos B, Bageritz J, Bermejo JL, Becker N, Engel F, Acker T, Momma S, Herold-Mende C, Lichter P, Radlwimmer B, Goidts V. Brain pathology (Zurich, Switzerland). 2013 Jan;23:60-72. [Full Text Article] [PubMed:22805276] Related Antibodies: LS-A1235, LS-A1232.

Immunostaining of Lgr5, an Intestinal Stem Cell Marker, in Normal and Premalignant Human Gastrointestinal Tissue. Becker L, Huang Q, Mashimo H. TheScientificWorldJournal. 2008 November;8:1168-1176. (IHC-P; Human) [Full Text Article] [PubMed:19030762] [PMC:PMC5848685] Related Antibodies: LS-A1235, LS-A1232.

Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis. Takeda K, Kinoshita I, Shimizu Y, Matsuno Y, Shichinohe T, Dosaka-Akita H. Anticancer research. 2011 Jan;31:263-70. [Full Text Article] [PubMed:21273608] Related Antibodies: LS-A1232.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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