GPR1 is a G protein-coupled receptor that binds chemerin. GPR1 was identified in a search for genes responsible for mediating brain reward and is thought to play a role in drug addiction. It has also been shown to act as an HIV coreceptor in kidney mesangial cells (Tokizawa et al., 2000). In immunohistochemistry, GPR1 has membranous positivity in the basal ganglia, pons and medulla, and corpus callosum in the brain, it is highly expressed in the placenta and is found in reproductive tissues, and it is also present in the esophagus, endocrine tissues, muscle, skin and at low levels throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804