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GPBAR1 / TGR5

G protein-coupled bile acid receptor 1

GPBAR1 / TGR5 is a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.

Gene Name: G protein-coupled bile acid receptor 1
Family/Subfamily: GPCR , Bile Acids
Synonyms: GPBAR1, BG37, GPR131, HGPCR19, M-BAR, GPCR19, TGR5, GPCR TGR5, HBG37, Membrane bile acid receptor
Target Sequences: AB083601 NP_733800.1 Q8TDU6

Publications (2)

1
Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism. Pathak P, Liu H, Boehme S, Xie C, Krausz KW, Gonzalez F, Chiang JYL. The Journal of biological chemistry. 2017 June;292:11055-11069. (Human) [Full Text Article] [PubMed:28478385] [PMC:PMC5491788] Related Antibodies: LS-C47388.
2
Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ. Molecular metabolism. 2018 May;11:84-95. (Human) [Full Text Article] [PubMed:29656109] [PMC:PMC6001409] Related Antibodies: LS-A1936.

☰ Filters
Antibodies (19)
ELISA Kits (8)
Proteins (5)
Custom (1)
Over-Expression Lysate (4)
Primary (19)
Recombinant (1)
Sandwich (7)
GPBAR1 / TGR5 (32)
Human (21)
Mouse (5)
Rat (8)
Bovine (1)
Chimpanzee (3)
IHC (6)
IHC-P (5)
WB (8)
Flo (1)
ELISA (4)
IF (3)
Peptide-ELISA (1)
rabbit (18)
mouse (1)
Product Group
GPCR Database Antibodies (4)
IHCPlus (3)
PathPlus Cancer (2)
IgG (7)
IgG2b (1)
monoclonal mc (1)
polyclonal pc (18)
409522 (1)
96-Well Strip Plate (8)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (16)
C-Terminus (6)
Cytoplasmic Domain (2)
aa298-330 (2)
30-110 aa, N-terminal (1)
Internal (1)
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aa11-60 (1)
aa250-300 (1)
No (30)
Yes (2)
Cell Lysates (2)
Plasma (4)
Serum (4)
Tissue Homogenates (3)
GST (1)
Myc-DDK (Flag) (4)
Human (3)
293T Cells (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
GPBAR1 / TGR5 Antibody - Anti-TGR5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC of human colon, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
GPBAR1 / TGR5 Antibody - Human Uterus, Endometrium: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
GPBAR1 / TGR5 Antibody - Western blot of BG37/TGR5 in spleen lysate. Lane 1 shows pre-immune sera. Lanes 2, 3 and 4 show antibody tested on human (1:1000), mouse (1:5000) and rat (1:5000) spleen lysate, respectively.
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$386
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GPBAR1 / TGR5 Mouse anti-Human Monoclonal (409522) Antibody
Human
Flo
Unconjugated
100 µg/$896
GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC staining of human small intestine, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$460
GPBAR1 / TGR5 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
GPBAR1 / TGR5 Antibody - Anti-TGR5 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
GPBAR1 / TGR5 Antibody - Immunofluorescence analysis of LOVO cells, using GPBAR Antibody. The picture on the right is blocked with the synthesized peptide.
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (aa11-60) Antibody
Human
IF, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
GPBAR1 / TGR5 Antibody - GPBAR1 / TGR5 antibody Western Blot of MCF7.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
GPBAR1 / TGR5 Antibody - GPBAR1 / TGR5 antibody Western Blot of MCF7.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human, Chimpanzee
WB
HRP Conjugated
100 µl/$469
GPBAR1 / TGR5 Antibody - GPBAR1 / TGR5 antibody Western Blot of MCF7.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
GPBAR1 / TGR5 Antibody - GPBAR1 / TGR5 antibody Western Blot of MCF7.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human, Chimpanzee
WB
FITC Conjugated
100 µl/$469
GPBAR1 / TGR5 Antibody - Western blot analysis of GPCR19 expression in HEK293T (A); Raw264.7 (B); PC12 (C) whole cell lysates.
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (30-110 aa, N-terminal) Antibody
Human
ELISA, IF
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GPBAR1 / TGR5 Antibody - Peptide - + Immunofluorescence analysis of LOVO cells, using GPBAR antibody.
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
100 µg/$357
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (aa298-330) Antibody
Human
IHC
Unconjugated
50 µl/$649
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (aa298-330) Antibody
Human
ELISA
Unconjugated
100 µg/$649
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (aa250-300) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$668
GPBAR1 / TGR5 Antibody - Western blot of GPBAR1 antibody at 1:500 dilution. Lane 1: HEK293T whole cell lysate. Lane 2: Raw264.7 whole cell lysate. Lane 3: PC12 whole cell lysate.
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GPBAR1 / TGR5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
GPBAR1 / TGR5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$1,041
GPBAR1 / TGR5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
GPBAR1 / TGR5 ELISA Kit
Select
Custom
96-Well Strip Plate
Bovine
Colorimetric - 450nm (TMB)
1 Plate/$783
GPBAR1 / TGR5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$1,034
GPBAR1 / TGR5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$893
Viewing 1-25 of 32 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).