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GIPR / GIP Receptor
gastric inhibitory polypeptide receptor
GIPR, or Gastric Inhibitory Polypeptide Receptor, mediates GIP-induced secretion of insulin by pancreatic islet beta cells after a meal. GIP is a gastrointestinal peptide hormone of 42 aa that is released from duodenal endocrine K cells after absorption of glucose or fat. Stimulation of the GIPR on pancreatic cells activates adenylyl cyclase and mitogen-activated protein kinase, resulting in increased insulin secretion. Mice with a targeted mutation of GIPR have higher blood glucose levels with impaired initial insulin response after oral glucose load. Analysis of GIPR knockout mice suggest that GIPR defects may contribute to the pathogenesis of diabetes and obesity. Ectopic expression of functional GIPR and its coupling to steroidogenesis has been suggested to be the main cause of food-dependent Cushing's syndrome. Two isoforms of GIPR are produced by alternative splicing.
| Gene Name: | gastric inhibitory polypeptide receptor |
| Family/Subfamily: | GPCR , Gastric inhibitory polypeptide |
| Synonyms: | GIPR, GIP receptor, PGQTL2, GIP-R |
| Target Sequences: | NM_000164 NP_000155.1 P48546 |
Publications (3)
1
Regulation of aldosterone secretion by several aberrant receptors including for glucose-dependent insulinotropic peptide in a patient with an aldosteronoma. Lampron A, Bourdeau I, Oble S, Godbout A, Schrch W, Arjane P, Hamet P, Lacroix A. The Journal of clinical endocrinology and metabolism. 2009 94:750-6. (IHC-P; Human)
[PubMed:19066304]
Related Antibodies: LS-A3840.
2
Coexistence of Myelolipoma and Primary Bilateral Macronodular Adrenal Hyperplasia With GIP-Dependent Cushing's Syndrome. Larose S, Bondaz L, Mermejo LM, Latour M, Prosmanne O, Bourdeau I, Lacroix A. Frontiers in endocrinology. 2019 September;10: [Full Text Article]
[PubMed:31572300]
[PMC:PMC6749096]
Related Antibodies: LS-A3840.
3
A case of ACTH-independent macronodular adrenal hyperplasia associated with multiple endocrine neoplasia type 1. Masanori Yoshida, Maiko Hiroi, Tsuneo Imai, Toyone Kikumori, Tatsuhito Himeno, Yasuhiro Nakamura, Hironobu Sasano, Masanobu Yamada, Yoshiko Murakami, Sigeo Nakamura, Yutaka Oiso. Endocrine Journal. 2011 March;58:269-77. [Full Text Article]
[PubMed:21415556]
Related Antibodies: LS-A3840.
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(36)
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GIPR / GIP Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
Neuroscience
Fast Shipping
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Dog, Bovine, Human
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (aa7-38) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
GIPR / GIP Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GIPR / GIP Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
GIPR / GIP Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
293T Cells
Myc-DDK (Flag)
53 kDa
20 µg/$150
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (aa93-142) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
GIPR / GIP Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (60-140 aa, Internal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GIPR / GIP Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (aa83-132) Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (aa104-136) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (aa104-136) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (aa104-136) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (aa104-136) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (aa104-136) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (aa104-136) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
GIPR / GIP Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (aa97-146) Antibody
Human
WB
Unconjugated
100 µl/$424
GIPR / GIP Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
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