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Catalog Number Size Price
LS-C744145-0.5 0.5 ml $764 
Antibody

Monoclonal Mouse anti‑Human GATA3 Antibody (IHC) LS‑C744145

Monoclonal Mouse anti‑Human GATA3 Antibody (IHC) LS‑C744145

Antibody:
GATA3 Mouse anti-Human Monoclonal Antibody
Application:
IHC-P
Reactivity:
Human, Rat
Format:
Unconjugated, Unmodified
Price
Catalog Number
$764
LS-C744145-0.5
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
GATA3 Mouse anti-Human Monoclonal Antibody
Application:
IHC-P
Reactivity:
Human, Rat
Format:
Unconjugated, Unmodified

Specifications

Description
GATA3 antibody LS-C744145 is an unconjugated mouse monoclonal antibody to GATA3 from human. It is reactive with human and rat. Validated for IHC.
Target
Human GATA3
Synonyms
GATA3 | GATA-binding factor 3 | HDRS | GATA binding protein 3 | GATA-binding protein 3 | HDR
Host
Mouse
Reactivity
Human, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal
Conjugations
Unconjugated
Modifications
Unmodified
Immunogen
Conserved peptide between the GATA trans-activation and DNA-binding domain
Applications
  • IHC - Paraffin (1:50 - 1:500)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
HIER (heat induced epitope retrieval) GATA3 (GATA binding protein 3 to DNA sequence [A/T]GATA[A/G]) is a zink finger transkription faktor and plays an important role in cell proliferation, development and differentiation in many tissues and cell types. Among other roles, GATA3 is involved in luminal cell differentiation in the mammary gland and appears to control a set of genes involved in the proliferation of breast cancer. GATA3 is primarily over-expressed in breast and urothelial carcinomas and only rarely found in tumors of other organs. Therefore anti-GATA3 has been used for diagnosis of unknown primary carcinoma, when carcinomas of the breast or bladder are a possibility. In a clinical study it was demonstated that GATA-3 stained 84% of urothelial carcinoma and 94% Mammacarcinoma (2). However, another study demonstates positivity for GATA3 in a number of other tumours (3), so that it is indicated to use more specific markers for differential diagnosis. For mamma carcinoma Mammaglobin and GCDFP should be used in addition to GATA3. GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3.
Presentation
PBS, 15 mM Sodium Azide, 0.2% BSA
Storage
Store at 2°C to 8°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About GATA3

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 1/18/2022