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GABRA4

gamma-aminobutyric acid (GABA) A receptor, alpha 4

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A receptor subtype. GABA-A receptors are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A receptor is a multimeric subunit complex. To date six alpha, four beta, and four gamma subunits, plus alternative splicing variants of some of these subunits, have been identified. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor.

Gene Name: gamma-aminobutyric acid (GABA) A receptor, alpha 4
Family/Subfamily: Ion Channel , GABA A receptor
Synonyms: GABRA4, GABA A receptor alpha 4, GABA(A) receptor, alpha 4
Target Sequences: NM_000809 NP_000800.2 P48169

Publications (2)

1
GABAA receptors are expressed and facilitate relaxation in airway smooth muscle. Mizuta K, Xu D, Pan Y, Comas G, Sonett JR, Zhang Y, Panettieri RA, Yang J, Emala CW. American journal of physiology. Lung cellular and molecular physiology. 2008 294:L1206-16. (WB; Guinea pig, Human) [PubMed:18408071]
2
Novel Expression of GABAA Receptors on Resistance Arteries That Modulate Myogenic Tone. Peter D Yim, George Gallos, Steven A Lee-Kong, William Dan, Amy D Wu, Dingbang Xu, Dan E Berkowitz, Charles W Emala. Journal of vascular Research. 2020 February;57:113-125. [Full Text Article] [PubMed:32097943] [PMC:PMC7228859]

☰ Filters
Antibodies (45)
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GABRA4 (48)
Human (45)
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monoclonal mc (9)
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aa333-361 (7)
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GABRA4 Antibody - Anti-GABRA4 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
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PathPlus™ GABRA4 Antibody (aa349-361) LS-B3611
Neuroscience
(5.0) Rating
GABRA4 Goat anti-Human Polyclonal (aa349-361) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
GABRA4 Antibody - GABRA4 Antibody IHC of formalin-fixed and paraffin-embedded brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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GABRA4 Antibody (aa350-377) LS-C166323
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
GABRA4 Antibody - Immunohistochemistry of paraffin-embedded human brain tissue using GABRA4 Antibody at dilution of 1:100
Select
GABRA4 Antibody (aa36-258) LS-C369648
GABRA4 Rabbit anti-Human Polyclonal (aa36-258) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
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GABRA4 Antibody (aa36-258, HRP) LS-C369649
GABRA4 Rabbit anti-Human Polyclonal (aa36-258) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
GABRA4 Antibody (aa36-258, FITC) LS-C369651
GABRA4 Rabbit anti-Human Polyclonal (aa36-258) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
GABRA4 Antibody - Immunohistochemical analysis of GABRA4 staining in rat brain;mouse brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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GABRA4 Antibody LS-C413661
GABRA4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
Select
GABRA4 Antibody (aa350-377) LS-C321523
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
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GABRA4 Antibody (aa350-377, Biotin) LS-C214506
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
Select
GABRA4 Antibody (aa350-377, FITC) LS-C214505
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
Select
GABRA4 Antibody (aa350-377, APC) LS-C214507
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
Select
GABRA4 Antibody (aa350-377, Azide-free, HRP) LS-C214509
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
GABRA4 Antibody (aa350-377, PE) LS-C214511
GABRA4 Rabbit anti-Human Polyclonal (aa350-377) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
GABRA4 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody, Clone S398A-34. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) GABA-A Receptor Alpha4 Antibody. (D) Composite.
Select
GABRA4 Antibody (clone S398A-34) LS-C774120
GABRA4 Mouse anti-Human Monoclonal (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
100 µg/$442
GABRA4 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody, Clone S398A-34. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) GABA-A Receptor Alpha4 Antibody. (D) Composite.
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GABRA4 Antibody (clone S398A-34, Biotin) LS-C774121
GABRA4 Mouse anti-Human Monoclonal (Biotin) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
Biotin Conjugated
100 µg/$475
GABRA4 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody, Clone S398A-34. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) GABA-A Receptor Alpha4 Antibody. (D) Composite.
Select
GABRA4 Antibody (clone S398A-34, FITC) LS-C774135
GABRA4 Mouse anti-Human Monoclonal (FITC) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
FITC Conjugated
100 µg/$472
GABRA4 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody, Clone S398A-34. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) GABA-A Receptor Alpha4 Antibody. (D) Composite.
Select
GABRA4 Antibody (clone S398A-34, APC) LS-C774124
GABRA4 Mouse anti-Human Monoclonal (APC) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
APC Conjugated
100 µg/$478
GABRA4 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody, Clone S398A-34. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) GABA-A Receptor Alpha4 Antibody. (D) Composite.
Select
GABRA4 Antibody (clone S398A-34, RPE) LS-C774126
GABRA4 Mouse anti-Human Monoclonal (RPE) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
RPE Conjugated
100 µg/$477
GABRA4 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody, Clone S398A-34. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) GABA-A Receptor Alpha4 Antibody. (D) Composite.
Select
GABRA4 Antibody (clone S398A-34, PerCP) LS-C774125
GABRA4 Mouse anti-Human Monoclonal (PerCP) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
PerCP Conjugated
100 µg/$478
GABRA4 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody, Clone S398A-34. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) GABA-A Receptor Alpha4 Antibody. (D) Composite.
Select
GABRA4 Antibody (clone S398A-34, AP) LS-C774122
GABRA4 Mouse anti-Human Monoclonal (AP) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
AP Conjugated
100 µg/$474
GABRA4 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody, Clone S398A-34. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) GABA-A Receptor Alpha4 Antibody. (D) Composite.
Select
GABRA4 Antibody (clone S398A-34, Atto 594) LS-C774131
GABRA4 Mouse anti-Human Monoclonal (Atto 594) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
Atto 594 Conjugated
100 µg/$479
GABRA4 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody, Clone S398A-34. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-GABA-A Receptor Alpha4 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) GABA-A Receptor Alpha4 Antibody. (D) Composite.
Select
GABRA4 Antibody (clone S398A-34, Atto 390) LS-C774127
GABRA4 Mouse anti-Human Monoclonal (Atto 390) (S398A-34) Antibody
Mouse, Rat, Human
IF, IHC, WB
Atto 390 Conjugated
100 µg/$479
Select
GABRA4 Antibody (aa333-361) LS-C321521
GABRA4 Rabbit anti-Human Polyclonal (aa333-361) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
Select
GABRA4 Antibody (aa333-361, PE) LS-C214503
GABRA4 Rabbit anti-Human Polyclonal (aa333-361) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
GABRA4 Antibody - Immunohistochemistry of paraffin-embedded human brain tissue at dilution 1:100
Select
GABRA4 Antibody LS-C675787
GABRA4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
GABRA4 Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Select
GABRA4 Antibody LS-C805066
GABRA4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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