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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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GABPA / NRF2 Antibody (aa14-178) LS-C389040

NRF2 antibody LS-C389040 is an unconjugated rabbit polyclonal antibody to NRF2 (GABPA) from human, mouse and rat. Validated for IHC and WB.
Catalog
Size
Price
LS-C389040-100
100 µg
$435
Description
NRF2 antibody LS-C389040 is an unconjugated rabbit polyclonal antibody to NRF2 (GABPA) from human, mouse and rat. Validated for IHC and WB.
Target
Human GABPA / NRF2
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (0.5 - 1 µg/ml)
  • Western blot (0.5 - 1 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
GABPA / NRF2 antibody was raised against human partial recombinant protein (aa14-178).
Epitope
aa14-178
Specificity
Human GABPA / NRF2
Usage
NFE2L2 (nuclear factor (erythroid-derived 2)-like 2) also known as NRF2 or NFE2-related transcription factor 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NFE2, NFE2L1, and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. NFE2L2 induces the expression of various genes including those that encode for several antioxidant enzymes, and it may play a physiological role in the regulation of oxidative stress. The NFE2L2 gene is located on 2q31.2. The identification of somatic mutations that disrupt the NRF2-KEAP1 interaction to stabilize NRF2 and increase the constitutive transcription of NRF2 target genes indicated that enhanced reactive oxygen species (ROS) detoxification and additional NRF2 functions may in fact be tumorigenic. Oncogene-directed increased expression of Nrf2 is a mechanism for the activation of the Nrf2 antioxidant program evident in primary cells and tissues of mice expressing KRas (G12D) and BRaf (V619E), and in human pancreatic cancer.
Presentation
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide.
Reconstitution
Sterile distilled water
Storage
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About GABPA / NRF2
Q06546 NM_002040 NP_002031.2

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Images

Immunohistochemistry

IHC-P: Nrf2 antibody testing of human lung cancer tissue
IHC-P: Nrf2 antibody testing of human lung cancer tissue

Western blot

Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD
Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD

Immunohistochemistry

IHC-P: Nrf2 antibody testing of human lung cancer tissue
IHC-P: Nrf2 antibody testing of human lung cancer tissue

Western blot

Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD
Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD

Immunohistochemistry

IHC-P: Nrf2 antibody testing of human lung cancer tissue
IHC-P: Nrf2 antibody testing of human lung cancer tissue

Western blot

Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD
Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD

Immunohistochemistry

IHC-P: Nrf2 antibody testing of human lung cancer tissue
IHC-P: Nrf2 antibody testing of human lung cancer tissue

Western blot

Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD
Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD

Requested From: United States
Date Requested: 4/23/2019
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