NRF2 antibody LS-C389040 is an unconjugated rabbit polyclonal antibody to NRF2 (GABPA) from human, mouse and rat. Validated for IHC and WB.
Human GABPA / NRF2
Human, Mouse, Rat
(tested or 100% immunogen sequence identity)
- IHC - Paraffin (0.5 - 1 µg/ml)
- Western blot (0.5 - 1 µg/ml)
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GABPA / NRF2 antibody was raised against human partial recombinant protein (aa14-178).
Human GABPA / NRF2
NFE2L2 (nuclear factor (erythroid-derived 2)-like 2) also known as NRF2 or NFE2-related transcription factor 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NFE2, NFE2L1, and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. NFE2L2 induces the expression of various genes including those that encode for several antioxidant enzymes, and it may play a physiological role in the regulation of oxidative stress. The NFE2L2 gene is located on 2q31.2. The identification of somatic mutations that disrupt the NRF2-KEAP1 interaction to stabilize NRF2 and increase the constitutive transcription of NRF2 target genes indicated that enhanced reactive oxygen species (ROS) detoxification and additional NRF2 functions may in fact be tumorigenic. Oncogene-directed increased expression of Nrf2 is a mechanism for the activation of the Nrf2 antioxidant program evident in primary cells and tissues of mice expressing KRas (G12D) and BRaf (V619E), and in human pancreatic cancer.
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide.
Sterile distilled water
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
For research use only.