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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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GABPA / NRF2 Antibody (aa14‑178) LS‑C389040
NRF2 antibody LS-C389040 is an unconjugated rabbit polyclonal antibody to NRF2 (GABPA) from human, mouse and rat. Validated for IHC and WB.
Catalog
Size
Price
LS-C389040-100
100 µg (0.5 mg/ml)
$405

Popular GABPA / NRF2 Products

GABPA antibody P100832_T100-NP_002031-GABPA (GA binding protein transcription factor, alpha subunit 60kDa) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Rabbit, Sheep, Chicken, Xenopus, Zebrafish
Applications: IHC, IHC - Paraffin, Western blot
Anti-GABPA / NRF2 antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, ICC, Western blot, Flow Cytometry
Antibody
Species: Human, Mouse, Rat
Applications: ICC, Western blot, Flow Cytometry
Immunoperoxidase of monoclonal antibody to GABPA on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml]
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Mouse, Human, Monkey, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Rabbit, Chicken, Xenopus
Applications: IHC, IHC - Paraffin, Western blot

Product Description

NRF2 antibody LS-C389040 is an unconjugated rabbit polyclonal antibody to NRF2 (GABPA) from human, mouse and rat. Validated for IHC and WB.

Specifications

Target
Human GABPA / NRF2
Synonyms
GABPA, E4TF1A, E4TF1-60, GA-binding protein alpha chain, NRF2A, RCH04A07, GABP subunit alpha, NFT2, NRF2, Transcription factor E4TF1-60
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (0.5 - 1 µg/ml)
  • Western blot (0.5 - 1 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
GABPA / NRF2 antibody was raised against human partial recombinant protein (aa14-178).
Epitope
aa14-178
Specificity
Human GABPA / NRF2
Usage
NFE2L2 (nuclear factor (erythroid-derived 2)-like 2) also known as NRF2 or NFE2-related transcription factor 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NFE2, NFE2L1, and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. NFE2L2 induces the expression of various genes including those that encode for several antioxidant enzymes, and it may play a physiological role in the regulation of oxidative stress. The NFE2L2 gene is located on 2q31.2. The identification of somatic mutations that disrupt the NRF2-KEAP1 interaction to stabilize NRF2 and increase the constitutive transcription of NRF2 target genes indicated that enhanced reactive oxygen species (ROS) detoxification and additional NRF2 functions may in fact be tumorigenic. Oncogene-directed increased expression of Nrf2 is a mechanism for the activation of the Nrf2 antioxidant program evident in primary cells and tissues of mice expressing KRas (G12D) and BRaf (V619E), and in human pancreatic cancer.
Presentation
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide.
Reconstitution
0.2 ml Sterile distilled water
Storage
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About GABPA / NRF2
GABPA / NRF2 is one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Q06546 NM_002040 NP_002031.2


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Images

Immunohistochemistry

IHC-P: Nrf2 antibody testing of human lung cancer tissue
IHC-P: Nrf2 antibody testing of human lung cancer tissue

Western blot

Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD
Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD

Immunohistochemistry

IHC-P: Nrf2 antibody testing of human lung cancer tissue
IHC-P: Nrf2 antibody testing of human lung cancer tissue

Western blot

Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD
Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD

Immunohistochemistry

IHC-P: Nrf2 antibody testing of human lung cancer tissue
IHC-P: Nrf2 antibody testing of human lung cancer tissue

Western blot

Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD
Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD

Immunohistochemistry

IHC-P: Nrf2 antibody testing of human lung cancer tissue
IHC-P: Nrf2 antibody testing of human lung cancer tissue

Western blot

Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD
Western blot testing of Nrf2 antibody and Lane 1: rat kidney; 2: human placenta; 3: mouse skeletal muscle; 4: mouse lung lysate; Predicted size: 68KD; Observed size: 100KD

Requested From: United States
Date Requested: 11/12/2018

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