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FZD3 / Frizzled 3
frizzled class receptor 3
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
| Gene Name: | frizzled class receptor 3 |
| Family/Subfamily: | GPCR , Frizzled |
| Synonyms: | FZD3, Frizzled family receptor 3, Frizzled 3, HFz3, Frizzled homolog 3, Fz-3, Wnt receptor frizzled-3, Frizzled-3 |
| Target Sequences: | NM_017412 NP_059108.1 Q9NPG1 |
Publications (2)
1
Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. Bengochea A, de Souza MM, Lefranois L, Le Roux E, Galy O, Chemin I, Kim M, Wands JR, Trepo C, Hainaut P, Scoazec JY, Vitvitski L, Merle P. British journal of cancer. 2008 99:143-50. (IHC-P; Human)
[Full Text Article]
[PubMed:18577996]
[PMC:PMC2453022]
Related Antibodies: LS-A4454.
2
Planar cell polarity protein localization in the secretory ameloblasts of rat incisors. Nishikawa S, Kawamoto T. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2012 May;60:376-85. [Full Text Article]
[PubMed:22378702]
[PMC:PMC3351231]
Related Antibodies: LS-A4434.
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FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal Antibody
IHC, IHC-P
Unconjugated
50 µg/$460
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
Cancer
Fast Shipping
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
FZD3 / Frizzled 3 Rat anti-Mouse Monoclonal Antibody
Mouse, Human
ELISA, Flo, IHC, IHC-Fr, WB
Unconjugated
100 µg/$941
FZD3 / Frizzled 3 Rat anti-Mouse Monoclonal (Biotin) Antibody
Mouse, Human
Flo, ICC, IHC, IHC-Fr, WB
Biotin Conjugated
100 µg/$839
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
100 µl/$450
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal (aa481-530) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
FZD3 / Frizzled 3 Goat anti-Mouse Polyclonal Antibody
Mouse
ICC, IHC, WB
Unconjugated
100 µg/$930
FZD3 / Frizzled 3 Goat anti-Human Polyclonal (aa569-581) Antibody
Human
Peptide-ELISA
Unconjugated
100 µg/$401
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal (110-190 aa, Internal) Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal (aa141-190) Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100 µg/$575
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal (Arg524) Antibody
Mouse, Human
IF, WB
Unconjugated
50 µl/$321; 100 µl/$403
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal (Leu180) Antibody
Mouse, Human
IF, WB
Unconjugated
50 µl/$321; 100 µl/$403
FZD3 / Frizzled 3 Mouse anti-Human Monoclonal (1B8) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal (aa496-525) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal (aa496-525) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
FZD3 / Frizzled 3 Rabbit anti-Human Polyclonal (aa131-180) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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