Mouse FOXP3

Mouse

Mouse, Human, Monkey (tested or 100% immunogen sequence identity)

IgG1,k Monoclonal

3G3

Unconjugated

Protein G purified

Unmodified. Also available Azide-free, BSA-free.

Full-length His-tagged mouse FOXP3 protein.

Mouse FOXP3

• Flow Cytometry (0.5 - 1 µg/10E6 cells)

Recognizes a protein of 47-55kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion (amino acids 2-136) of the protein.The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation. The optimal dilution of the FOXP3 antibody for each application should be determined by the researcher.

1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide

Store at 2°C to 8°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q9BZS1 NCBI: NM_014009 NP_054728.2