Human FOS / c-FOS

Rabbit

Human, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Sheep (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Synthetic peptide (DQLEDEKSALQTEIANLL, aa170-187 of UniProt P01100) was used as the immunogen for this c-Fos antibody (100% homologous in human, mouse and rat). Percent identity by BLAST analysis: Human, Mouse, Rat, Ferret, Sheep, Cat, Bovine, Bat, Hamster, Rabbit, Horse, Pig, Opossum, Guinea pig, Platypus, Dog (100%); Elephant (94%); Zebra finch, Chicken, Zebrafish (89%); Trout, Medaka, Pufferfish (83%).

aa170-187

Human FOS / c-FOS

• Western blot (0.5 - 1 µg/ml)

The human oncogene c-Fos is the cellular homolog of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus which was mapped to a single human chromosome. The protein is encoded by the FOS gene. It was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family. c-Fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation. Using transgenic and knockout mice, Grigoriadis et al. (1995) established a unique role for the proto-oncogene and nuclear transcription factor in regulating the differentiation and activity of specific bone cell populations, both during normal development and in bone disease.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P01100 NCBI: NM_005252 NP_005243.1