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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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FGFR1 / FGF Receptor 1 Antibody (FITC) LS-C498845

Antibody

FGFR1 / FGF Receptor 1 Antibody (FITC) LS-C498845

Antibody:
Rabbit Polyclonal to Human FGFR1 / FGF Receptor 1
Application:
ELISA
Reactivity:
Human
Format:
FITC, Unmodified
Other formats:
Price
Catalog Number
$285 
LS-C498845-50
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human FGFR1 / FGF Receptor 1
Application:
ELISA
Reactivity:
Human
Format:
FITC, Unmodified
Other formats:

Specifications

Description
FGF Receptor 1 antibody LS-C498845 is an FITC-conjugated rabbit polyclonal antibody to human FGF Receptor 1 (FGFR1). Validated for ELISA.

Target
Human FGFR1 / FGF Receptor 1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
FITC. Also available Unconjugated or conjugated with HRP, Biotin.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • ELISA
  • (applications tested for the base form of this product only)
Immunogen
Recombinant Human Fibroblast growth factor receptor 1 protein (22-96AA)
Specificity
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About FGFR1 / FGF Receptor 1
P11362 NM_023110 CAA47375.1

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Requested From: United States
Date Requested: 6/25/2019
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