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FGF2 / Basic FGF
fibroblast growth factor 2 (basic)
FGF2 / Basic FGF is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
| Gene Name: | fibroblast growth factor 2 (basic) |
| Family/Subfamily: | HBGF , not assigned-HBGF |
| Synonyms: | FGF2, Basic fibroblast growth factor, FGFB, Fibroblast growth factor 2, FGF-2, Prostatropin, BFGF, HBGF-2 |
| Target Sequences: | NM_002006 NP_001997.5 P09038 |
Publications (1)
1
A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma10<sup> Washington University School of Medicine, St. Louis, MO, USA12<sup> Memorial Sloan Kettering Cancer Center, New York, NY, USA14<sup> GlaxoSmithKline, Inc., 1250 South Collegeville Road, Collegeville, PA, USA16<sup> Utrecht University, Utrecht, The Netherlands18<sup> Phase I Trials Unit, Medical Oncology Department, Hospital Universitario Virgen de. Emilie M J van Brummelen, Evgeny Levchenko, Manuel Dómine, Dean A Fennell, Hedy L Kindler, Santiago Viteri, Shirish Gadgeel, Pilar Garrido López, Vladimir Kostorov, Daniel Morgensztern, Sergey Orlov, Marjorie G Zauderer, Johan F Vansteenkiste, Katherine Baker-Neblett, James Vasquez, Xiaowei Wang, David I Bellovin, Jan H M Schellens, Li Yan, Ionel Mitrica, M Phillip DeYoung, José Trigo. Investigational new drugs. 2020 Apr;;38:457-467. [Full Text Article]
[PubMed:31065954]
[PMC:PMC6898757]
Related Antibodies: LS-B10042.
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FGF2 / Basic FGF Mouse anti-Human Monoclonal (3D9) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
Neuroscience
FGF2 / Basic FGF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Neuroscience
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (aa 143-288) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
FGF2 / Basic FGF Mouse anti-Bovine Monoclonal Antibody
Mouse, Bovine, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$463; 500 µg/$925
FGF2 / Basic FGF Rabbit anti-Bovine Polyclonal Antibody
Bovine, Pig, Human
IHC, RIA, WB
Unconjugated
20 µl/$488; 100 µl/$957
FGF2 / Basic FGF Rabbit anti-Mouse Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
Sandwich
96-Well Microplate
Pig
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Competitive EIA
96-Well Strip Plate
Mouse
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
E. coli
His
16.2 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
FGF2 / Basic FGF Rabbit anti-Human Polyclonal (aa219-249) Antibody
Rat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
E. coli
His, N-Terminal
17 kDa
10 µg/$265; 100 µg/$365; 50 µg/$315
FGF2 / Basic FGF Mouse anti-Human Monoclonal (OTI3D10) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
Sandwich
96-Well Strip Plate
Sheep
6.25 - 400 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$911
Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
12 x 8-Well Microstrips
Human
63 - 400 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$479
Sandwich
96-Well Microplate
Bovine
4.1 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$672
Sandwich
96-Well Strip Plate
Guinea pig
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Strip Plate
Human
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Sandwich
96-Well Strip Plate
Rabbit
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
FGF2 / Basic FGF Mouse anti-Human Monoclonal (2H5G2C11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 ml/$380
FGF2 / Basic FGF Mouse anti-Bovine Monoclonal Antibody
Bovine, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
500 µg/$1,042
FGF2 / Basic FGF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Neut, WB
Unconjugated
50 µg/$494
FGF2 / Basic FGF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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