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Catalog Number Size Price
LS-C43020-0.1 0.1 mg (1 mg/ml) $525 
FEN1 Antibody - Detection of human Fen1 in whole cell lysates of HeLa and 293T cells (5-50 ug/lane) by Western blotting with Rabbit anti-Human Fen1 (RABBIT ANTI HUMAN FEN1). Immunoprecipitation was with RABBIT ANTI HUMAN FEN1 (3 ug/mg lysate) or another anti-Fen1 polyclonal antibody, subsequent detection of immunoprecipitated Fen1 by Western blotting used RABBIT ANTI HUMAN FEN1.

Polyclonal Rabbit anti‑Human FEN1 Antibody (N‑Terminus, WB) LS‑C43020

Polyclonal Rabbit anti‑Human FEN1 Antibody (N‑Terminus, WB) LS‑C43020

Antibody:
FEN1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
WB, IP
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$525
LS-C43020-0.1
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
FEN1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
WB, IP
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
FEN1 antibody LS-C43020 is an unconjugated rabbit polyclonal antibody to human FEN1 (N-Terminus). Validated for IP and WB.
Target
Human FEN1
Synonyms
FEN1 | DNase IV | FEN-1 | HFEN-1 | Flap endonuclease 1 | MF1 | RAD2 | Maturation factor 1 | Maturation factor-1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Immunogen
Synthetic peptide corresponding to a region within the N-Terminus domain of human FEN1 (locus link ID 2237).
Epitope
N-Terminus
Specificity
Recognizes human Flap endonuclease 1 also known as Flap structure-specific endonuclease, FEN1, Maturation factor 1 or DNase IV. FEN1 is a 380 amino acid ~45kD member of the FEN1 sub family of XPG/RAD2 endonucleases which has an important role in lagging strand DNA synthesis and base excision repair. It is hypothesised that FEN1 may play a role in the inhibition of triplet repeat expansion. Two isoforms of FEN1 are generated by alternative initiation, isoform 1 against whichis generated and a truncated isoform FENMIT, lacking the N-terminal region and having a mitochondrial distribution, FENMIT also lacks DNAse activity. Initial results suggest thatdoes not recognize the truncated form of human FEN1. Fen1 is expressed in the nucleus of a wide variety of organ structures notably in those of the hematopoietic system including spleen, lymph nodes and spleen. Recognizes a band of ~45kD in whole cell lysates of HeLa and 293T by western blotting and has successfully been used for immunoprecipitation of FEN1 from HeLa cell lysates.
Applications
  • Western blot (1:5000 - 1:30000)
  • Immunoprecipitation
Usage
Western Blot: LS-C43020 detects a band of approximately 42kD in Hela cell lysates.
Presentation
Tris-Citrate/PBS, 0.09% Sodium Azide
Storage
Store at 4°C. Do not freeze. Store undiluted. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About FEN1
P39748 NM_004111 NP_004102.1

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/27/2021