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FBN1 / Fibrillin 1

fibrillin 1

Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.

Gene Name: fibrillin 1
Synonyms: FBN1, ACMICD, Fibrillin 1, Fibrillin-1, FBN, ECTOL1, GPHYSD2, MASS, MFS1, OCTD, SSKS, WMS2, Fibrillin 1 (Marfan syndrome), Fibrillin 15, SGS, WMS
Target Sequences: NM_000138 P35555

Publications (3)

1
Defining the Extracellular Matrix of Rhabdomyosarcoma. Xiaolei Lian, J Steffan Bond, Narendra Bharathy, Sergei P Boudko, Elena Pokidysheva, Jack F Shern, Melvin Lathara, Takako Sasaki, Teagan Settelmeyer, Megan M Cleary, Ayeza Bajwa, Ganapati Srinivasa, Christopher P Hartley, Hans Peter Bächinger, Atiya Mansoor, Sakir H Gultekin, Noah E Berlow, Charles Keller. Frontiers in oncology. 2021 March;11:601957. [Full Text Article] [PubMed:33708626] [PMC:PMC7942227] Related Antibodies: LS-B5512.
2
FBXO2 Promotes Proliferation of Endometrial Cancer by Ubiquitin-Mediated Degradation of FBN1 in the Regulation of the Cell Cycle and the Autophagy Pathway. Xiaoxia Che, Fangfang Jian, Ying Wang, Jingjing Zhang, Jian Shen, Qi Cheng, Xi Wang, Nan Jia, Weiwei Feng. Frontiers in cell and developmental biology. 2020 September;8:843. [Full Text Article] [PubMed:32984335] [PMC:PMC7487413] Related Antibodies: LS-B5512.
3
Impairment of chondrogenesis and microfibrillar network in Adamtsl2 deficiency. Laure Delhon, Clémentine Mahaut, Nicolas Goudin, Emilie Gaudas, Kevin Piquand, Wilfried Le Goff, Valérie Cormier-Daire, Carine Le Goff. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 Feb;33:2707-2718. [Full Text Article] [PubMed:30303737] Related Antibodies: LS-C358981.

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FBN1 / Fibrillin 1 (170)
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aa723-902 (11)
aa168-364 (10)
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FBN1 / Fibrillin 1 Antibody - Anti-FBN1 / Fibrillin 1 antibody IHC of human prostate, extra cellular matrix. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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FBN1 / Fibrillin 1 Mouse anti-Human Monoclonal (aa45-450) (26) Antibody
Chicken, Bovine, Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
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FBN1 / Fibrillin 1 Mouse anti-Human Monoclonal (PE) Antibody
Chicken, Bovine, Human
ELISA, IF, IP, WB
PE Conjugated
100 µl/$1,149
FBN1 / Fibrillin 1 Antibody - ICC/IF analysis of Fibrillin 1 staining in Jurkat cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 ??C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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FBN1 / Fibrillin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IF, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
FBN1 / Fibrillin 1 Antibody - Anti-FBN1 / Fibrillin 1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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FBN1 / Fibrillin 1 Mouse anti-Human Monoclonal (3H6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
FBN1 / Fibrillin 1 Antibody - Anti-FBN1 / Fibrillin 1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FBN1 / Fibrillin 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
FBN1 / Fibrillin 1 Antibody - Western blot of FBN1 antibody
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FBN1 / Fibrillin 1 Rabbit anti-Human Polyclonal (2780-2860 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
FBN1 / Fibrillin 1 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
27.4 - 20000 pg/ml
Chemiluminescent
Plasma, Serum, Tissue Homogenates
1 Plate/$968
FBN1 / Fibrillin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
FBN1 / Fibrillin 1 Antibody - IHCanalysis of Fibrillin-1 (N2843) pAb in paraffin-embedded human breast carcinoma tissue.
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FBN1 / Fibrillin 1 Rabbit anti-Human Polyclonal (Asn2843) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
50 µl/$321; 100 µl/$403
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FBN1 / Fibrillin 1 Rabbit anti-Human Polyclonal (aa723-902) (Biotin) Antibody
Human
ICC, WB
Biotin Conjugated
100 µl/$307
FBN1 / Fibrillin 1 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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FBN1 / Fibrillin 1 Rabbit anti-Human Polyclonal Antibody
Bovine, Human
ELISA, ICC, IHC-P
Unconjugated
50 µl/$485
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FBN1 / Fibrillin 1 Mouse anti-Human Monoclonal (aa2093-2871) Antibody
Chicken, Bovine, Human
ELISA, IF, IP, WB
Unconjugated
100 µg/$854
FBN1 / Fibrillin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
312.24 kDa
20 µg/$215
FBN1 / Fibrillin 1 Protein - Recombinant Fibrillin 1 By SDS-PAGE
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E. coli
6His, N-terminus
20.8 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
FBN1 / Fibrillin 1 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Fibrillin-1 Antibody. The picture on the right is blocked with the synthesized peptide.
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FBN1 / Fibrillin 1 Rabbit anti-Human Polyclonal (aa2811-2860) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
FBN1 / Fibrillin 1 Antibody - Western blot of recombinant FBN1 / Fibrillin 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FBN1 / Fibrillin 1 Rabbit anti-Mouse Polyclonal (aa1701-1887) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
FBN1 / Fibrillin 1 Antibody - Western blot of recombinant FBN1 / Fibrillin 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FBN1 / Fibrillin 1 Rabbit anti-Human Polyclonal (aa246-389) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
FBN1 / Fibrillin 1 Antibody - Western Blot; Sample: Recombinant FBN1, Human.
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FBN1 / Fibrillin 1 Rabbit anti-Human Polyclonal (aa723-902) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$336; 500 µl/$462; 1 ml/$525; 2 ml/$677; 5 ml/$1,136
FBN1 / Fibrillin 1 Antibody - Western blot of recombinant FBN1 / Fibrillin 1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FBN1 / Fibrillin 1 Rabbit anti-Mouse Polyclonal (aa1701-1887) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$319
FBN1 / Fibrillin 1 Antibody - Western Blot; Sample: Recombinant FBN1, Rat.
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FBN1 / Fibrillin 1 Rabbit anti-Rat Polyclonal (aa751-895) Antibody
Rat
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
FBN1 / Fibrillin 1 Antibody - 1:100 staining human ovarian carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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FBN1 / Fibrillin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
FBN1 / Fibrillin 1 Protein
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E. coli
6His, N-terminus
22.7 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
FBN1 / Fibrillin 1 Protein - Recombinant Fibrillin 1 By SDS-PAGE
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E. coli
His-GST
47.2 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
FBN1 / Fibrillin 1 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
FBN1 / Fibrillin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Viewing 1-25 of 170 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).