ESRRA / ERR Alpha

estrogen-related receptor alpha

Estrogen-related receptor alpha (ERR alpha), a NR3 Steroid Receptor, was isolated based on sequence similarity in its DNA-binding domain to estrogen receptor alpha (ER alpha). ERR alpha has been shown to regulate the promoters of lactoferrin, medium-chain acyl CoA dehydrogenase, osteopontin, and thyroid receptor alpha, and it may affect cellular energy balance and bone formation. ERR alpha binds as a monodimer to the extended half-site TNAAGGTCA and as a homodimer to the estrogen response element (ERE) and is a constitutive activator of the estrogen response element and the palindromic thyroid hormone response element (TRE) but not of the glucocorticoid response element (GRE). ERR alpha 1 is the major isoform expressed in human breast cancer cell lines. Recent studies have shown that Phe-329 is responsible for the constitutive activity of ERR alpha. ERR alpha is a potential biomarker for unfavorable clinical outcome and, possibly, hormonal insensitivity in breast tumors. ERR alpha status may be predictive of sensitivity to hormonal blockade therapy, and ERR alpha status may also be predictive of ErbB2-based therapy such as Herceptin. Moreover, ERR alpha may be a candidate target for therapeutic development. ERRalpha null mice have altered regulation of genes involved in adipogenesis

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ESRRA / ERR Alpha (89)

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PathPlus™ ESRRA / ERR Alpha Antibody (Internal) LS-A5402

Neuroscience

Fast Shipping

(5.0) Rating

(5) Publication(s)

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey

Applications:

ChrIP, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ ESRRA / ERR Alpha Antibody (Ligand-binding Domain) LS-A5480

Fast Shipping

(5.0) Rating

(1) Publication(s)

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal (Ligand-binding Domain) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$440

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ESRRA / ERR Alpha Antibody (aa339-364) LS-C65724

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal (aa339-364) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$832

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ESRRA / ERR Alpha Antibody (APC) LS-C516666

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Mouse, Rat, Hamster, Human

Applications:

IHC, IP, WB

Format:

APC Conjugated

Price:

100 µl/$1,054

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ESRRA / ERR Alpha Antibody (PE) LS-C654078

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Mouse, Rat, Hamster, Human

Applications:

IHC, IP, WB

Format:

PE Conjugated

Price:

100 µl/$1,054

• Unconjugated
• APC
• PE

• Unconjugated
• APC
• PE

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ESRRA / ERR Alpha Antibody (aa131-159) LS-C167833

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal (aa131-159) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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ESRRA / ERR Alpha Antibody (clone 6F1E6) LS-C682397

Antibody:

ESRRA / ERR Alpha Mouse anti-Human Monoclonal (6F1E6) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

100 µl/$459

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ESRRA / ERR Alpha Antibody LS-C833259

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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Human ESRRA / ERR Alpha Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65569

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.3 kDa

Price:

20 µg/$1,107

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Human ESRRA / ERR Alpha Protein (Recombinant GST, N-terminus) (aa1-423) - LS-G56247

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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ESRRA / ERR Alpha Antibody (aa1-205, clone OTI2C12) LS-C794450

Antibody:

ESRRA / ERR Alpha Mouse anti-Human Monoclonal (aa1-205) (OTI2C12) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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ESRRA / ERR Alpha Antibody (aa1-205, clone OTI2C12, Carrier-free) LS-C798575

Antibody:

ESRRA / ERR Alpha Mouse anti-Human Monoclonal (aa1-205) (Carrier-free) (OTI2C12) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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ESRRA / ERR Alpha Antibody LS-C123496

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$489

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ESRRA / ERR Alpha Antibody LS-C123497

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$489

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ESRRA / ERR Alpha Antibody (aa1-205, clone OTI3E3) LS-C794451

Antibody:

ESRRA / ERR Alpha Mouse anti-Human Monoclonal (aa1-205) (OTI3E3) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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ESRRA / ERR Alpha Antibody (aa1-205, clone OTI3E3, Carrier-free) LS-C791724

Antibody:

ESRRA / ERR Alpha Mouse anti-Human Monoclonal (aa1-205) (Carrier-free) (OTI3E3) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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ESRRA / ERR Alpha Antibody LS-C749195

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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ESRRA / ERR Alpha Antibody LS-C816318

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF

Format:

Unconjugated

Price:

100 µl/$412

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ESRRA / ERR Alpha Antibody (aa1-423) LS-C375682

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal (aa1-423) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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ESRRA / ERR Alpha Antibody (clone 1A6E11) LS-C669527

Antibody:

ESRRA / ERR Alpha Mouse anti-Human Monoclonal (1A6E11) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

100 µl/$459

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ESRRA / ERR Alpha Antibody LS-C123494

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µg/$489

Select

ESRRA / ERR Alpha Antibody LS-C123495

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µg/$489

Select

ESRRA / ERR Alpha Antibody LS-C128891

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µg/$680

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ESRRA / ERR Alpha Antibody LS-C348942

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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ESRRA / ERR Alpha Antibody (aa1-50) LS-C143407

Antibody:

ESRRA / ERR Alpha Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Dog, Rat, Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

0.1 ml/$386

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