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| Catalog Number | Size | Price |
|---|---|---|
| LS-C357879-100 | 100 µg | $575 |
Polyclonal Rabbit anti‑Human ESR2 / ER Beta Antibody (aa27‑50, WB) LS‑C357879
Polyclonal Rabbit anti‑Human ESR2 / ER Beta Antibody (aa27‑50, WB) LS‑C357879
Antibody:
ESR2 / ER Beta Rabbit anti-Human Polyclonal (aa27-50) Antibody
Application:
WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
ESR2 / ER Beta Rabbit anti-Human Polyclonal (aa27-50) Antibody
Application:
WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
ER Beta antibody LS-C357879 is an unconjugated rabbit polyclonal antibody to human ER Beta (ESR2) (aa27-50). Validated for WB.
Target
Human ESR2 / ER Beta
Synonyms
ESR2 | ESTRB | ER Beta | ERbeta | ER-BETA | ESR-BETA | ESRB | Estrogen receptor 2 (ER beta) | NR3A2 | Estrogen receptor beta | Estrogen receptor beta 4
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Chimpanzee, Orangutan, Gibbon, Monkey (at least 90% immunogen sequence identity)
Clonality
IgG
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
A synthetic peptide corresponding to a sequence at the N-Terminus of human Estrogen Receptor beta(27-50 aa HGSIYIPSSYVDSHHEYPAMTFYS). Percent identity by BLAST analysis: Human, Gorilla (100%); Chimpanzee, Orangutan, Baboon, Monkey (96%); Gibbon, Marmoset (92%); Elephant (88%); Mouse, Rat, Cat, Bat (83%).
Epitope
aa27-50
Specificity
Human ESR2 / ER Beta
Applications
- Western blot (0.5 - 1 µg/ml)
Usage
Estrogen receptor-beta, referred to as ESR2, is a member of the superfamily of nuclear receptors, which can transduce extracellular signals into transcriptional responses. This gene is mapped to 14q and comprises 8 exons spanning approximately 40 kb. ESR2 is expressed in multiple tissues, including developing spermatids of the testis and in ovarian granulosa cells. ESR-beta is homologous to the previously identified ESR-alpha and has an overlapping but nonidentical tissue distribution. The DNA-binding domain of ESR-beta is 96% conserved compared to ESR, and the ligand-binding domain shows 58% conserved residues. ESR-beta is expressed in human thymus, spleen, ovary, and testis. Rat ESR-beta is expressed in rat prostate and ovary and is homologous to rat ESR(95% conserved DNA-binding domain. 55% conserved ligand-binding domain). ESR2 mRNA was coexpressed with ESR1 and its splice variants in 60% of prolactinomas, 100% of mixed growth hormone /prolactin tumors, and 29% of gonadotroph tumors. ESR2 gene expression was not limited to ESR1-positive tumor subtypes, however, and was also found in 100% of null cell tumors, 80% of somatotroph tumors, and 60% of corticotroph tumors.
Presentation
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
Reconstitution
Reconstitute in sterile distilled water.
Storage
Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About ESR2 / ER Beta
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Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Mouse
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot
Species:
Human, Mouse, Rat
Applications:
Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human, Mouse, Rat, Dog
Applications:
ICC, Immunofluorescence, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC, Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/23/2024
Date Requested: 4/23/2024
