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ERN1 / IRE1
endoplasmic reticulum to nucleus signaling 1
The endoribonuclease IRE1/ERN1 encodes the ER-to-nucleus signaling 1 protein, a human homolog of the yeast Ire1 gene product. In S. cerevisiae, as well as in human, this ER transmembrane IRE serine/threonine protein kinase monitors the status of unfolded proteins inside the ER lumen in response to stress. Activation of ERN1 leads to oligomerization, autophosphorylation, and proteolytic cleavage. The kinase and nuclease domains are then transported into the nucleus to function as a site-specific endoribonuclease. ERN1 activates JNK and other chaperone genes in response to stress.
| Gene Name: | endoplasmic reticulum to nucleus signaling 1 |
| Family/Subfamily: | Protein Kinase , IRE |
| Synonyms: | ERN1, ER to nucleus signalling 1, Inositol-requiring enzyme 1, Inositol-requiring protein 1, Ire1-alpha, IRE1a, HIRE1p, IRE1, Inositol-requiring 1, IRE1P |
| Target Sequences: | NM_001433 NP_001424.3 O75460 |
Publications (4)
1
Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation. Kubota K, Lee DH, Tsuchiya M, Young CS, Everett ET, Martinez-Mier EA, Snead ML, Nguyen L, Urano F, Bartlett JD. The Journal of biological chemistry. 2005 280:23194-202.
[PubMed:15849362]
2
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. Fonseca SG, Fukuma M, Lipson KL, Nguyen LX, Allen JR, Oka Y, Urano F. The Journal of biological chemistry. 2005 280:39609-15. (ICC, IHC, WB; Mouse, Primate)
[PubMed:16195229]
3
AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. Luo D, He Y, Zhang H, Yu L, Chen H, Xu Z, Tang S, Urano F, Min W. The Journal of biological chemistry. 2008 283:11905-12.
[PubMed:18281285]
[PMC:PMC2335342]
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ERN1 / IRE1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
ERN1 / IRE1 Rabbit anti-Human Polyclonal (aa700-800) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
ERN1 / IRE1 Rabbit anti-Human Polyclonal (aa700-800) (Biotin) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
ERN1 / IRE1 Rabbit anti-Human Polyclonal (aa700-800) (DY650) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
ERN1 / IRE1 Rabbit anti-Human Polyclonal (aa700-800) (DY488) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
ERN1 / IRE1 Rabbit anti-Human Polyclonal (aa700-800) (DY550) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ERN1 / IRE1 Mouse anti-Human Monoclonal (9F2) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$834
ERN1 / IRE1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, WB
Unconjugated
0.1 mg/$460
Baculovirus
His-GST, N-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human ERN1/GST chimera consists of 750 amino acids and has a calculated molecular mass of 86 kDa. It migrates as an approximately 90 kDa band in SDS-PAGE under reducing conditions.
50 µg/$410
Sandwich
96-Well Microplate
Mouse
39.063 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ERN1 / IRE1 Mouse anti-Human Monoclonal (3D1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ERN1 / IRE1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
ERN1 / IRE1 Rabbit anti-Human Polyclonal (pSer724) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ERN1 / IRE1 Goat anti-Human Polyclonal (aa699-711) Antibody
Rabbit, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
HEK 293 Cells
Myc-DDK (Flag)
109.6 kDa
20 µg/$1,107
E. coli
His-T7
33.3 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ERN1 / IRE1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
ERN1 / IRE1 Mouse anti-Human Monoclonal (Amino Acid: 282-433) (9F2) Antibody
Human
IHC, WB
Unconjugated
100 µl/$518
ERN1 / IRE1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ERN1 / IRE1 Mouse anti-Human Monoclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$296; 100 µl/$341; 200 µl/$421
ERN1 / IRE1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$294; 100 µg/$360
ERN1 / IRE1 Rabbit anti-Mouse Polyclonal (aa827-855) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
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