Human EIF4EBP1 / 4EBP1

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

A 14 AA peptide located near human 4EBP1 C-Terminus.

C-Terminus

Recognizes an epitope within the C-terminal region (CT) of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1), a rapamycin-sensitive downstream target of TOR (Target of rapamycin), and regulatory factor of eukaryotic mRNA translation. The association between 4EPB1 and eukaryotic translation initiation factor 4E (eIF-4E) inhibits the binding of eIF-4E with p220, thereby preventing the formation of a functional eIF-4E complex, essential for mRNA translation. Phosphorylation of 4EBP1 following stimulation by mitogens such as insulin, results in the release of eIF-4E from 4EBP1, thereby enabling the translation complex to assemble.(AHP993) has been reported as suitable for use in IHC on mouse 3T3 cell cytospins.

• Western blot (2.5 - 5 µg/ml)

Western Blot: LS-C43158 detects a band of approximately 20kD in mouse 3T3 cell lysates. (predicted MW 13kD).

PBS, 0.02% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q13541 NCBI: NM_004095 NP_004086.1