Human EIF4EBP1 / 4EBP1
EIF4EBP1 | 4E-BP1 | 4EBP1 | BP-1 | PHAS-I | EIF4E-binding protein 1
(tested or 100% immunogen sequence identity)
A 14 AA peptide located near human 4EBP1 C-Terminus.
Recognizes an epitope within the C-terminal region (CT) of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1), a rapamycin-sensitive downstream target of TOR (Target of rapamycin), and regulatory factor of eukaryotic mRNA translation. The association between 4EPB1 and eukaryotic translation initiation factor 4E (eIF-4E) inhibits the binding of eIF-4E with p220, thereby preventing the formation of a functional eIF-4E complex, essential for mRNA translation. Phosphorylation of 4EBP1 following stimulation by mitogens such as insulin, results in the release of eIF-4E from 4EBP1, thereby enabling the translation complex to assemble.(AHP993) has been reported as suitable for use in IHC on mouse 3T3 cell cytospins.