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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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EDN1 / Endothelin 1 Antibody (C-Terminus, clone 1C4) LS-C11319

Endothelin 1 antibody LS-C11319 is an unconjugated mouse monoclonal antibody to Endothelin 1 (EDN1) from human and monkey. Validated for IHC and RIA. Cited in 1 publication.
Catalog
Size
Price
LS-C11319-0.1
0.1 mg
$335
Description
Endothelin 1 antibody LS-C11319 is an unconjugated mouse monoclonal antibody to Endothelin 1 (EDN1) from human and monkey. Validated for IHC and RIA. Cited in 1 publication.
Target
Human EDN1 / Endothelin 1
Host
Mouse
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Clone
1C4
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Frozen
  • Radioimmunoassay
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
C-terminal fragment of human endothelin 1.
Epitope
C-Terminus
Specificity
Recognizes human endothelin 1 (ET-1). Endothelin-1 in it's precursor form is a 212 amino acid protein with a 17 aa signal peptide, an N-terminal pro-peptide region and a C-terminal pro-peptide region flanking the endothelin peptides, big endothelin-1 (38aa), the precursor of the smaller endothelin peptide which is cleaved by endothelin converting enzyme to produce the active endothelin-1 (21aa) peptide and a c-terminal fragment. Endothelin-1 is a potent vasoconstrictor with a molecular weight of approximately 25 kD. Shows less than 10% reactivity with endothelin 3. Plasma levels of both endothelin-1 and big endothelin-1 are useful as predictors for survival of patients with congestive heart failure. However, the half life of the endothlin1 peptide in human plasma is very short (c1.0mins) and measurement of big-endothelin-1 may be a more reliable measure of the endothelin secretory pathway activity.
Presentation
PBS, pH 7.2, 0.09% Sodium Azide
Storage
Short term: -20°C; Long term: -20°C.
Restrictions
For research use only.
About EDN1 / Endothelin 1
P05305 NM_001955 NP_001946.3

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Publications (1)

1
Estrogen and progesterone regulate expression of the endothelins in the rhesus macaque endometrium. Keator CS, Mah K, Ohm L, Slayden OD. Human reproduction (Oxford, England). 2011 26:1715-28. (IHC-Fr; Monkey) [Full Text Article] [PubMed:21505040] [PMC:PMC3113504]

Customer Reviews (0)


Requested From: United States
Date Requested: 4/22/2019
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