Endothelin 1 antibody LS-C11319 is an unconjugated mouse monoclonal antibody to Endothelin 1 (EDN1) from human and monkey. Validated for IHC and RIA. Cited in 1 publication.
Human EDN1 / Endothelin 1
(tested or 100% immunogen sequence identity)
Protein A purified
- IHC - Frozen
See our complete line of Immunohistochemistry Reagents
including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
C-terminal fragment of human endothelin 1.
Recognizes human endothelin 1 (ET-1). Endothelin-1 in it's precursor form is a 212 amino acid protein with a 17 aa signal peptide, an N-terminal pro-peptide region and a C-terminal pro-peptide region flanking the endothelin peptides, big endothelin-1 (38aa), the precursor of the smaller endothelin peptide which is cleaved by endothelin converting enzyme to produce the active endothelin-1 (21aa) peptide and a c-terminal fragment. Endothelin-1 is a potent vasoconstrictor with a molecular weight of approximately 25 kD. Shows less than 10% reactivity with endothelin 3. Plasma levels of both endothelin-1 and big endothelin-1 are useful as predictors for survival of patients with congestive heart failure. However, the half life of the endothlin1 peptide in human plasma is very short (c1.0mins) and measurement of big-endothelin-1 may be a more reliable measure of the endothelin secretory pathway activity.
PBS, pH 7.2, 0.09% Sodium Azide
Short term: -20°C; Long term: -20°C.
For research use only.
About EDN1 / Endothelin 1