E2F7

E2F transcription factor 7

Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.

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Products

Antibodies (18)

Proteins (3)

Type

Over-Expression Lysate (2)

Primary (18)

Recombinant (1)

Target

E2F7 (21)

Reactivity

Human (14)

Mouse (6)

Rat (4)

Guinea pig (3)

Monkey (2)

Application

IHC (3)

WB (16)

ELISA (9)

IP (1)

Peptide-ELISA (2)

Host

rabbit (17)

goat (1)

Isotype

IgG (15)

Clonality

polyclonal pc (18)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (10)

Epitope

aa591-619 (7)

aa108-157 (4)

aa1-50 (1)

aa53-66 (1)

Publications

No (21)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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E2F7 Antibody LS-C750184

Antibody:

E2F7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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E2F7 Antibody (aa591-619) LS-C167600

Antibody:

E2F7 Rabbit anti-Human Polyclonal (aa591-619) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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E2F7 Antibody (aa1-50) LS-C289739

Antibody:

E2F7 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

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E2F7 Antibody LS-C665252

Antibody:

E2F7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

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E2F7 Antibody LS-C804076

Antibody:

E2F7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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E2F7 Antibody LS-C402247

Antibody:

E2F7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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E2F7 Antibody (aa591-619) LS-C320995

Antibody:

E2F7 Rabbit anti-Human Polyclonal (aa591-619) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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E2F7 Antibody (aa591-619, Biotin) LS-C234830

Antibody:

E2F7 Rabbit anti-Human Polyclonal (aa591-619) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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E2F7 Antibody (aa591-619, FITC) LS-C234831

Antibody:

E2F7 Rabbit anti-Human Polyclonal (aa591-619) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

E2F7 Antibody (aa591-619, Azide-free, HRP) LS-C249883

Antibody:

E2F7 Rabbit anti-Human Polyclonal (aa591-619) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

E2F7 Antibody (aa591-619, APC) LS-C234829

Antibody:

E2F7 Rabbit anti-Human Polyclonal (aa591-619) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

E2F7 Antibody (aa591-619, PE) LS-C234834

Antibody:

E2F7 Rabbit anti-Human Polyclonal (aa591-619) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

Select

E2F7 Antibody LS-C781529

Antibody:

E2F7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

E2F7 Antibody (aa108-157) LS-C31453

Antibody:

E2F7 Rabbit anti-Mouse Polyclonal (aa108-157) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

Select

E2F7 Antibody (aa108-157, HRP) LS-C435734

Antibody:

E2F7 Rabbit anti-Mouse Polyclonal (aa108-157) (HRP) Antibody

Reactivity:

Mouse, Guinea pig, Rat

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$442

Select

E2F7 Antibody (aa108-157, Biotin) LS-C435733

Antibody:

E2F7 Rabbit anti-Mouse Polyclonal (aa108-157) (Biotin) Antibody

Reactivity:

Mouse, Guinea pig, Rat

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$442

Select

E2F7 Antibody (aa108-157, FITC) LS-C435736

Antibody:

E2F7 Rabbit anti-Mouse Polyclonal (aa108-157) (FITC) Antibody

Reactivity:

Mouse, Guinea pig, Rat

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$442

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

E2F7 Antibody (aa53-66) LS-C112753

Antibody:

E2F7 Goat anti-Human Polyclonal (aa53-66) Antibody

Reactivity:

Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

Human E2F7 Protein (Recombinant GST, N-terminus) (aa801-910) - LS-G63698

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human E2F7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93019

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.7 kDa

Price:

20 µg/$215

Select

E2F7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103114

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.7 kDa

Price:

100 µg/$710

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