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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DNMT / DNMT1 Antibody (N‑Terminus) LS‑C2652
DNMT1 antibody LS-C2652 is an unconjugated rabbit polyclonal antibody to DNMT1 (DNMT) from human and mouse. Validated for IP and WB.
Catalog
Size
Price
LS-C2652-100
100 µl
$335

Popular DNMT / DNMT1 Products

Anti-DNMT1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4353 concentration 3.75 ug/ml.
Species: Human, Monkey, Mouse, Rat, Bovine, Dog, Horse, Pig, Rabbit, Sheep
Applications: IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Anti-DNMT1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2128 concentration 5 ug/ml.
Species: Human, Monkey, Mouse, Bat, Horse, Rabbit
Applications: IHC, IHC - Paraffin, Western blot, Immunoprecipitation, Chromatin Immunoprecipitation
Anti-DNMT1 antibody IHC of mouse lymphoid tissue. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5632 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Mouse
Applications: IHC, IHC - Paraffin, Western blot
Anti-DNMT1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B800 concentration 10 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, ELISA
Antibody
Species: Human
Applications: Western blot, Flow Cytometry, ELISA

Product Description

DNMT1 antibody LS-C2652 is an unconjugated rabbit polyclonal antibody to DNMT1 (DNMT) from human and mouse. Validated for IP and WB.

Specifications

Target
Human DNMT / DNMT1
Synonyms
DNMT1, AIM, CXXC finger protein 9, CXXC9, DNA methyltransferase 1, DNMT, DNA methyltransferase HsaI, DNA MTase HsaI, HSN1E, M.HsaI, MCMT
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Modifications
Unmodified
Applications
  • Western blot (1:5000)
  • Immunoprecipitation (1:1000)
Immunogen
DNMT / DNMT1 antibody was raised against the first 10 kD of the N-terminus of the DNMT1 protein
Epitope
N-Terminus
Specificity
DNMT1.
Presentation
Whole antisera
Storage
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.
Restrictions
For research use only.
About DNMT / DNMT1
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. P26358 NM_001379 NP_001370.1


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Images

Western blot

Western blot of antibody to detect DNMT1 levels in T24 cells. Lane 1:50 ugs of total protein lysate from untreated T24 cells. Lane 2:50 ugs of total protein lysate treated with 0.5 uM 5-Aza-Deoxycytidine for 3 days.
Western blot of antibody to detect DNMT1 levels in T24 cells. Lane 1:50 ugs of total protein lysate from untreated T24 cells. Lane 2:50 ugs of total protein lysate treated with 0.5 uM 5-Aza-Deoxycytidine for 3 days.

Western blot

Western blot of antibody to detect DNMT1 levels in T24 cells. Lane 1:50 ugs of total protein lysate from untreated T24 cells. Lane 2:50 ugs of total protein lysate treated with 0.5 uM 5-Aza-Deoxycytidine for 3 days.
Western blot of antibody to detect DNMT1 levels in T24 cells. Lane 1:50 ugs of total protein lysate from untreated T24 cells. Lane 2:50 ugs of total protein lysate treated with 0.5 uM 5-Aza-Deoxycytidine for 3 days.

Western blot

Western blot of antibody to detect DNMT1 levels in T24 cells. Lane 1:50 ugs of total protein lysate from untreated T24 cells. Lane 2:50 ugs of total protein lysate treated with 0.5 uM 5-Aza-Deoxycytidine for 3 days.
Western blot of antibody to detect DNMT1 levels in T24 cells. Lane 1:50 ugs of total protein lysate from untreated T24 cells. Lane 2:50 ugs of total protein lysate treated with 0.5 uM 5-Aza-Deoxycytidine for 3 days.

Western blot

Western blot of antibody to detect DNMT1 levels in T24 cells. Lane 1:50 ugs of total protein lysate from untreated T24 cells. Lane 2:50 ugs of total protein lysate treated with 0.5 uM 5-Aza-Deoxycytidine for 3 days.
Western blot of antibody to detect DNMT1 levels in T24 cells. Lane 1:50 ugs of total protein lysate from untreated T24 cells. Lane 2:50 ugs of total protein lysate treated with 0.5 uM 5-Aza-Deoxycytidine for 3 days.

Requested From: United States
Date Requested: 10/15/2018

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