DMD / Dystrophin

dystrophin

The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix.

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Antibodies (37)

ELISA Kits (25)

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Sandwich (16)

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DMD / Dystrophin (79)

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Human (33)

Mouse (23)

Rat (14)

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Dog (1)

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rabbit (32)

mouse (5)

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IgG1,k (1)

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monoclonal mc (5)

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96-Well Strip Plate (20)

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aa3059-3314 (8)

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Cell Culture Supernatants (2)

Cell Lysates (2)

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DMD / Dystrophin Antibody (aa3076-3404) LS-C357462

Antibody:

DMD / Dystrophin Rabbit anti-Human Polyclonal (aa3076-3404) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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DMD / Dystrophin Antibody (clone 3A11) LS-C197060

Antibody:

DMD / Dystrophin Mouse anti-Human Monoclonal (3A11) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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Human DMD / Dystrophin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68048

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

143 kDa

Price:

20 µg/$1,107

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Human DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F11308

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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Human DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F4776

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Mouse DMD / Dystrophin (Sandwich ELISA) ELISA Kit - LS-F7170

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$818

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DMD / Dystrophin Antibody (C-Terminus) LS-C50556

Antibody:

DMD / Dystrophin Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC

Format:

Unconjugated

Price:

250 µl/$490

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DMD / Dystrophin Antibody (aa3059-3314) LS-C293718

Antibody:

DMD / Dystrophin Rabbit anti-Mouse Polyclonal (aa3059-3314) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206

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DMD / Dystrophin Antibody (aa3059-3314, Biotin) LS-C685977

Antibody:

DMD / Dystrophin Rabbit anti-Mouse Polyclonal (aa3059-3314) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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DMD / Dystrophin Antibody LS-C121744

Antibody:

DMD / Dystrophin Mouse anti-Human Monoclonal Antibody

Reactivity:

Chicken, Mouse, Rat, Human

Applications:

IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

100 µg/$564

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Human DMD / Dystrophin Protein (Recombinant His) (aa3048-3328) - LS-G13921

Source:

E. coli

Tag:

His

Molecular Weight:

33.7 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Mouse DMD / Dystrophin Protein (Recombinant His) (aa3059-3314) - LS-G13924

Source:

E. coli

Tag:

His

Molecular Weight:

30.8 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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DMD / Dystrophin Antibody (clone DYS-48) LS-C171138

Antibody:

DMD / Dystrophin Mouse anti-Human Monoclonal (DYS-48) Antibody

Reactivity:

Chicken, Mouse, Rat, Human

Applications:

IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

100 µg/$380

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DMD / Dystrophin Antibody (C-Terminus) LS-C22980

Antibody:

DMD / Dystrophin Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

250 µl/$585

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DMD / Dystrophin Antibody (clone DYS-48, Magnetic beads) LS-C171139

Antibody:

DMD / Dystrophin Mouse anti-Human Monoclonal (Magnetic beads) (DYS-48) Antibody

Reactivity:

Chicken, Mouse, Rat, Human

Applications:

IP

Format:

Magnetic beads Conjugated

Price:

100 µg/$399

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DMD / Dystrophin Antibody (aa3048-3328, HRP) LS-C709814

Antibody:

DMD / Dystrophin Rabbit anti-Human Polyclonal (aa3048-3328) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511

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IHC-plus™ DMD / Dystrophin Antibody LS-B14375

(4.0) Rating

Antibody:

DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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Mouse DMD / Dystrophin (Competitive EIA) ELISA Kit - LS-F28303

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

1 - 25 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

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DMD / Dystrophin Antibody LS-C665114

Antibody:

DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

DMD / Dystrophin Antibody LS-C807358

Antibody:

DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

DMD / Dystrophin Antibody LS-C680391

Antibody:

DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

DMD / Dystrophin Antibody (HRP) LS-C680393

Antibody:

DMD / Dystrophin Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP

• Unconjugated
• HRP

Select

DMD / Dystrophin Antibody LS-C310206

Antibody:

DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

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DMD / Dystrophin Antibody (HRP) LS-C541902

Antibody:

DMD / Dystrophin Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$937

• Unconjugated
• HRP

• Unconjugated
• HRP

Select

DMD / Dystrophin Antibody LS-C777789

Antibody:

DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC-P

Format:

Unconjugated

Price:

100 µg/$357

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