DENN / MADD

MAP-kinase activating death domain

MAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor necrosis factor receptor (TNFR1) associated protein though their death domains. Overexpression of MADD activates MAP kinases ERK and JNK and induces the phosphorylation of cytosolic phospholipase A2 (1). MADD shares 98% identity with DENN (for differentially expressed in neoplastic vs. normal cells), which was recently identified as a substrate for c-jun N-terminal kinase 3 (JNK3). MADD has greater than 94% overall identity to a GDP/GTP exchange protein Rab3-GEP. MADD is 87% identical to KIAA0358, a brain protein of unknown function. Identification of MADD as a component of the TNFR1 signaling complex and the similarity between MADD and Rab3-GEP provides a connection between TNFR1 activation and downstream MAP kinase activity through a guanine-nucleotide exchange protein.

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Products

Antibodies (11)

Proteins (4)

ELISA Kits (1)

Type

Cell-Based (1)

Over-Expression Lysate (4)

Primary (11)

Target

DENN / MADD (16)

Reactivity

Human (12)

Mouse (7)

Rat (7)

Monkey (1)

Application

IHC (8)

IHC-P (4)

WB (8)

ELISA (3)

ICC (2)

IF (8)

IP (3)

Peptide-ELISA (3)

Host

rabbit (11)

Product Group

IHCPlus (2)

Isotype

IgG (10)

Clonality

polyclonal pc (11)

Format

96-Well Microplate (1)

Unconjugated (11)

Epitope

aa1597-1647 (2)

720-800 aa, Internal (1)

Internal (1)

aa1100-1150 (1)

aa729-778 (1)

aa751-800 (1)

Publications

No (16)

Sample Type

Adherent Cell Cultures (1)

Tag

Myc-DDK (Flag) (4)

Species

Human (2)

Source

293T Cells (2)

HEK 293 Cells (2)

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IHC-plus™ DENN / MADD Antibody LS-B583

(4.0) Rating

Antibody:

DENN / MADD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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DENN / MADD Antibody (720-800 aa, Internal) LS-C384399

Antibody:

DENN / MADD Rabbit anti-Human Polyclonal (720-800 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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IHC-plus™ DENN / MADD Antibody (aa1597-1647) LS-B14430

(4.0) Rating

Antibody:

DENN / MADD Rabbit anti-Human Polyclonal (aa1597-1647) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, IP

Format:

Unconjugated

Price:

50 µl/$460

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DENN / MADD Antibody LS-C823103

Antibody:

DENN / MADD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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DENN / MADD Antibody (aa751-800) LS-C119176

Antibody:

DENN / MADD Rabbit anti-Human Polyclonal (aa751-800) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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DENN / MADD Antibody LS-C809287

Antibody:

DENN / MADD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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DENN / MADD Antibody (aa1597-1647) LS-C285973

Antibody:

DENN / MADD Rabbit anti-Human Polyclonal (aa1597-1647) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P

Format:

Unconjugated

Price:

1 µg/$295; 100 µl/$532

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DENN / MADD Antibody LS-C816648

Antibody:

DENN / MADD Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF

Format:

Unconjugated

Price:

100 µl/$412

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DENN / MADD Antibody (aa729-778) LS-C292152

Antibody:

DENN / MADD Rabbit anti-Human Polyclonal (aa729-778) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

DENN / MADD Antibody (aa1100-1150) LS-C288896

Antibody:

DENN / MADD Rabbit anti-Human Polyclonal (aa1100-1150) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

DENN / MADD Antibody (Internal) LS-C353071

Antibody:

DENN / MADD Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human, Monkey

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$299

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Human DENN / MADD Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79760

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

183.1 kDa

Price:

20 µg/$215

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Human DENN / MADD Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79762

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

176.9 kDa

Price:

20 µg/$215

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DENN / MADD Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107632

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

176.9 kDa

Price:

100 µg/$710

Select

Mouse/Human/Rat DENN / MADD (Cell-Based ELISA) ELISA Kit - LS-F3267

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

Select

DENN / MADD Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117157

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

183.1 kDa

Price:

100 µg/$710

Viewing 1-16 of 16 product results

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