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DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5' to 3' direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5'-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complex activities. Stimulates the flap endonuclease activity of FEN1. Required for normal sister chromatid cohesion. Required for recruitment of bovine papillomavirus type 1 regulatory protein E2 to mitotic chrmosomes and for viral genome maintenance. Required for maintaining the chromosome segregation and is essential for embryonic development and the prevention of aneuploidy. May function during either S, G2, or M phase of the cell cycle. Binds to both single- and double-stranded DNA.
Gene Name: | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 |
Family/Subfamily: | DEAD box protein |
Synonyms: | DDX11, CHL1-related helicase gene-1, CHLR1, CHL1-related protein 1, CHL1-like helicase homolog, KRG2, WABS, DEAD/H box protein 11, HCHLR1, KRG-2 |
Target Sequences: | NM_030653 NP_085911.2 A8MPP1 |
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