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DDC / DOPA Decarboxylase
dopa decarboxylase (aromatic L-amino acid decarboxylase)
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
| Gene Name: | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
| Family/Subfamily: | Carboxy-lyase , Not assigned-Other |
| Synonyms: | DDC, AADC, DOPA decarboxylase |
| Target Sequences: | NM_000790 NP_000781.1 P20711 |
Publications (2)
1
Dopamine synthesis and dopamine receptor expression are disturbed in recurrent miscarriages. Gratz MJ, Stavrou S, Kuhn C, Hofmann S, Hermelink K, Heidegger H, Hutter S, Mayr D, Mahner S, Jeschke U, Vattai A. Endocrine connections. 2018 May;7:727-738. (Human)
[Full Text Article]
[PubMed:29686031]
[PMC:PMC5958746]
Related Antibodies: LS-B10123.
2
Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma. Yan Yan, Jiahao Pan, Yonghua Chen, Wei Xing, Qiang Li, Dongyin Wang, Xiaoshuang Zhou, Jingdun Xie, Changhong Miao, Yunfei Yuan, Weian Zeng, Dongtai Chen. Cancer communications (London, England). 2020 December;40:694-710. [Full Text Article]
[PubMed:33017522]
[PMC:PMC7743025]
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Neuroscience
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
Neuroscience
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Dog, Guinea pig, Sheep, Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal (aa32-61) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
DDC / DOPA Decarboxylase Rabbit anti-Human Monoclonal (Preservative Free) (003) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal (aa32-61) Antibody
Mouse, Human
ELISA, Flo, IF, IHC-P, WB
Unconjugated
200 µl/$734
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal (aa32-61) (Biotin) Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal (aa32-61) (FITC) Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal (aa32-61) (PE) Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal (aa32-61) (APC) Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal (aa32-61) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
DDC / DOPA Decarboxylase Rabbit anti-Mouse Polyclonal (aa1-480) Antibody
Mouse
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$412
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Xenopus, Horse, Mouse, Dog, Guinea pig, Human, Monkey, Chimpanzee, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Xenopus, Horse, Mouse, Dog, Guinea pig, Human, Monkey, Chimpanzee, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$442
DDC / DOPA Decarboxylase Mouse anti-Human Monoclonal (aa1-480) (413911) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$896
DDC / DOPA Decarboxylase Mouse anti-Human Monoclonal (N-Terminus) Antibody
Rabbit, Dog, Guinea pig, Sheep, Bovine, Rat, Human, Monkey
ELISA, WB
Unconjugated
100 µl/$860
DDC / DOPA Decarboxylase Mouse anti-Human Monoclonal (8E8) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
DDC / DOPA Decarboxylase Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$379
DDC / DOPA Decarboxylase Rabbit anti-Bovine Polyclonal Antibody
Bovine
IHC, WB
Unconjugated
100 µl/$842
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