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CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2E1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
| Gene Name: | cytochrome P450, family 2, subfamily E, polypeptide 1 |
| Family/Subfamily: | Cytochrome P450 , not assigned-Cytochrome P450 |
| Synonyms: | CYP2E1, 4-nitrophenol 2-hydroxylase, CPE1, Cytochrome p450 IIe1, Cytochrome P450-J, p450C2E, p450-J, CYP2E, CYPIIE1, Cytochrome P450 2E1 |
| Target Sequences: | NM_000773 NP_000764.1 P05181 |
Publications (3)
1
Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment. Zhao Shan, Leike Li, Constance Lynn Atkins, Meng Wang, Yankai Wen, Jongmin Jeong, Nicolas F Moreno, Dechun Feng, Xun Gui, Ningyan Zhang, Chun Geun Lee, Jack A Elias, William M Lee, Bin Gao, Fong Wilson Lam, Zhiqiang An, Cynthia Ju. eLife. 2021 June;10: [Full Text Article]
[PubMed:34110284]
[PMC:PMC8233036]
Related Antibodies: LS-C6332.
2
Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation. Xiao-Wei Zhang, Ji-Chao Zhou, Dian Peng, Fang Hua, Ke Li, Jiao-Jiao Yu, Xiao-Xi Lv, Bing Cui, Shan-Shan Liu, Jin-Mei Yu, Feng Wang, Cai-Cai Jin, Zhao-Na Yang, Chen-Xi Zhao, Xue-Ying Hou, Bo Huang, Zhuo-Wei Hu. Autophagy. 2020 May;;16:782-796. [Full Text Article]
[PubMed:31286822]
[PMC:PMC7144866]
3
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Boj SF, van Es JH, Huch M, Li VS, Jos[Character e9] A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H. Cell. 2012 Dec;151:1595-607. [Full Text Article]
[PubMed:23260145]
Related Antibodies: LS-C6332.
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CYP2E1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CYP2E1 Rabbit anti-Rat Polyclonal Antibody
Rabbit, Mouse, Dog, Guinea pig, Rat, Horse, Human, Monkey
WB
Unconjugated
50 µg/$665; 200 µg/$1,058
CYP2E1 Rabbit anti-Mouse Polyclonal (aa94-112) Antibody
Mouse, Rat
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$764
Sandwich
96-Well Strip Plate
Mouse
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$782
CYP2E1 Rabbit anti-Human Polyclonal (aa402-429) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CYP2E1 Goat anti-Human Polyclonal (aa233-243) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CYP2E1 Rabbit anti-Human Polyclonal (C-Terminus) (Magnetic beads) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
CYP2E1 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$515
CYP2E1 Rabbit anti-Human Polyclonal (aa1-310) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CYP2E1 Rabbit anti-Human Polyclonal (aa371-420) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
100 µl/$515
CYP2E1 Mouse anti-Human Monoclonal (OTI5F11) Antibody
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
CYP2E1 Mouse anti-Human Monoclonal (Carrier-free) (OTI5F11) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CYP2E1 Mouse anti-Human Monoclonal (OTI5B9) Antibody
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
CYP2E1 Mouse anti-Human Monoclonal (Carrier-free) (OTI5B9) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CYP2E1 Rabbit anti-Mouse Polyclonal (aa34-273) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
CYP2E1 Rabbit anti-Human Polyclonal (aa352-401) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
CYP2E1 Mouse anti-Human Monoclonal (OTI9E6) Antibody
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
CYP2E1 Mouse anti-Human Monoclonal (Carrier-free) (OTI9E6) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CYP2E1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
CYP2E1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CYP2E1 Goat anti-Rabbit Polyclonal Antibody
Rabbit, Rat
WB
Unconjugated
100 µl/$558
CYP2E1 Rabbit anti-Human Polyclonal (340-420 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CYP2E1 Rabbit anti-Human Polyclonal (aa49-288) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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