Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(tested or 100% immunogen sequence identity)
Western blot (1 µg/ml)
A synthetic peptide made to a C-terminal portion of the human aromatase protein sequence (between residues 400-502). Homology: 100% Mk, 91% Eq, 90% Bv, Rb, 83% Po, 81% Sh, Gt, and Ca.
This antibody is specific for aromatase. Species cross-reactivity: This antibody reacts with human aromatase protein. The immunogen used for this antibody production has 100% homology with monkey, 91% with horse, 90% with bovine and rabbit, 83% with porcine, and 81% with sheep, goat, and canine. There is no significant homology with rat or mouse protein.
Suitable for use in ELISA and Western Blot. Western Blot: 1 ug/ml (ECL). A band is seen at ~55kD.
CYP19 / Aromatase is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis.