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CXCR3
chemokine (C-X-C motif) receptor 3
CXCR3 is a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
| Gene Name: | chemokine (C-X-C motif) receptor 3 |
| Family/Subfamily: | GPCR , Chemokine |
| Synonyms: | CXCR3, C-x-c chemokine receptor 3, CD183 antigen, CKR-L2, CXCR-3, CMKAR3, CD182, CD183, Cxcr3a, GPR9, IP-10 receptor, IP10-R, Mig receptor, MigR, Mig-R, Chemokine (C-X-C) receptor 3, CXC-R3, Cxcr3b, G protein-coupled receptor 9, IP10 receptor |
| Target Sequences: | NM_001504 NP_001495.1 P49682 |
Publications (5)
1
Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. Denkert C, Loibl S, Noske A, Roller M, Mller BM, Komor M, Budczies J, Darb-Esfahani S, Kronenwett R, Hanusch C, von Trne C, Weichert W, Engels K, Solbach C, Schrader I, Dietel M, von Minckwitz G. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010 28:105-13. (IHC-P; Human)
[PubMed:19917869]
Related Antibodies: LS-C6283.
2
Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints. Mikucki ME, Fisher DT, Matsuzaki J, Skitzki JJ, Gaulin NB, Muhitch JB, Ku AW, Frelinger JG, Odunsi K, Gajewski TF, Luster AD, Evans SS. Nature communications. 2015 6:7458. (Block; Human)
[Full Text Article]
[PubMed:26109379]
[PMC:PMC4605273]
Related Antibodies: LS-C6283.
3
CXCR3 regulates CD4+ T cell cardiotropism in pressure overload-induced cardiac dysfunction. Ngwenyama N, Salvador AM, Velázquez F, Nevers T, Levy A, Aronovitz M, Luster AD, Huggins GS, Alcaide P. JCI insight. 2019 April;4:pii: 125527. [Full Text Article]
[PubMed:30779709]
[PMC:PMC6483643]
Related Antibodies: LS-B10183.
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CXCR3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
Neuroscience
Fast Shipping
CXCR3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
CXCR3 Mouse anti-Human Monoclonal (2AR1) Antibody
Human
Flo, Func, IHC, Neut
Unconjugated
100 µg/$962
CXCR3 Mouse anti-Human Monoclonal (CF) (2AR1) Antibody
Human
Flo
CF Conjugated
1 ml/$755
CXCR3 Mouse anti-Human Monoclonal (PE) (2AR1) Antibody
Human
Flo
PE Conjugated
1 ml/$872
CXCR3 Rabbit anti-Human Polyclonal (aa289-368) Antibody
Mouse, Human
IHC-P, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CXCR3 Rabbit anti-Human Polyclonal (aa161-210) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
CXCR3 Rabbit anti-Human Polyclonal (aa290-303) Antibody
Mouse, Human
WB
Unconjugated
100 µg/$386
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CXCR3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
CXCR3 Goat anti-Human Polyclonal (aa399-410) Antibody
Human, Monkey
IF, Peptide-ELISA
Unconjugated
100 µg/$503
CXCR3 Mouse anti-Human Monoclonal (APC) (G025H7) Antibody
Human
Flo
APC Conjugated
20 Tests/$263; 100 Tests/$367; 200 Tests/$445
CXCR3 Mouse anti-Human Monoclonal (PE) (G025H7) Antibody
Human
Flo
PE Conjugated
20 Tests/$261; 100 Tests/$346; 200 Tests/$415
CXCR3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
CXCR3 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
CXCR3 Mouse anti-Human Monoclonal (5C10E6) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
CXCR3 Rabbit anti-Human Polyclonal (aa338-349) Antibody
Human
WB
Unconjugated
100 µg/$649
CXCR3 Hamster-Armenian anti-Mouse Monoclonal (AF647) (CXCR3-173) Antibody
Mouse
Flo
AF647 Conjugated
50 Tests/$260; 100 Tests/$291; 200 Tests/$348
CXCR3 Mouse anti-Human Monoclonal (5C10B3) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
CXCR3 Rabbit anti-Human Polyclonal (aa140-167) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
CXCR3 Rabbit anti-Human Polyclonal (aa140-167) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
CXCR3 Rabbit anti-Human Polyclonal (aa140-167) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
CXCR3 Rabbit anti-Human Polyclonal (aa140-167) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
CXCR3 Rabbit anti-Human Polyclonal (aa140-167) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$782
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