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| Catalog Number | Size | Price |
|---|---|---|
| LS-A86-50 | 50 µg (1 mg/ml) | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human CX3CR1 Antibody (Extracellular Domain, IHC) LS‑A86
PathPlus™ Polyclonal Rabbit anti‑Human CX3CR1 Antibody (Extracellular Domain, IHC) LS‑A86
Antibody:
CX3CR1 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Overview
Antibody:
CX3CR1 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Chemokine (C-X3-C motif) receptor 1 (CX3CR1) is an HIV coreceptor and also a leukocyte chemotactic/adhesion receptor for fractalkine, also known as neurotactin. CX3CR1 mediates chemotactic responses to the soluble form of fractalkine in neutrophils and T cells, and cytoadhesion to cells expressing membrane-anchored fractalkine, such as monocytes, T cells, and neutrophils. Cells transfected with CX3CR1 exhibited chemotaxis and transient increases in intracellular calcium concentration when exposed to fractalkine.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human CX3CR1
Synonyms
CX3CR1 | Beta chemokine receptor-like 1 | C-X3-C CKR-1 | Chemokine (C-X3-C) receptor 1 | CMKBRL1 | CMK-BRL-1 | CMKDR1 | CMK-BRL1 | CX3C chemokine receptor 1 | Fkn receptor | GPR13 | GPRV28 | Fractalkine receptor | G protein-coupled receptor v28 | G-protein coupled receptor 13 | V28 | Chemokine c-x3-c receptor 1 | G protein-coupled receptor 13
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 19 amino acid peptide from 3rd extracellular domain of human CX3CR1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon, Monkey (95%); Marmoset, Mouse, Panda (84%).
Epitope
Extracellular Domain
Specificity
Human CX3CR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (5 - 10 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistochemistry: The unconjugated form was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for the unconjugated form was determined to be 5-10 ug/ml.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CX3CR1
Validation
Lymph node, Hodgkin's lymphoma
Lymph node, Hodgkin's lymphoma
Skin, Melanoma
Skin, Melanoma
Anti-CX3CR1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CX3CR1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ CX3CR1 Antibody (Extracellular Domain) for IHC LS-A86 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (1)
Up-regulation of CX3CR1 on tonsillar CD8-positive cells in patients with IgA nephropathy. Otaka R, Takahara M, Ueda S, Nagato T, Kishibe K, Nomura K, Katada A, Hayashi T, Harabuchi Y. Human immunology. 2017 78:375-383. (IHC; Human)
Customer Reviews (0)
Featured Products
Species:
Human, Mouse, Rat
Applications:
IHC, Immunofluorescence, Western blot, Flow Cytometry, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/18/2024
Date Requested: 4/18/2024
