Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Mouse, Rat
(tested or 100% immunogen sequence identity)
IHC - Frozen
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Purified full length native protein (Human lung cancer line EPLC 32 M1). Epitope: Recognizes an epitope within amino acid residues GYGFEST (265-271 in procathepsin ul and 169-175 in the mature cathepsin ul molecule).
Reacts specifically with the native and denatured forms of human cathepsin ul (25kD) and procathepsin ul (42kD). Does not react with human cathepsin types B1, D1, H and S1, procathepsins B and D1 and recombinant procathepsin H, rat cathepsin B1, and mouse procathepsins B1 and D1. Species cross-reactivity: Cross-reacts with Human, Mouse procathepsin ul (weak), Rat cathepsin ul (strong), and Mink cathepsin and procathepsin L.
Suitable for use in ELISA, Western Blot and Immunohistochemistry (Fr). Positive control: Whole cell extract from cultured mink lung cell line.
CTSL / Cathepsin L is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria.