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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CTSK / Cathepsin K Antibody (aa115‑329) LS‑C408068
Cathepsin K antibody LS-C408068 is an unconjugated rabbit polyclonal antibody to human Cathepsin K (CTSK). Validated for IHC and WB.
Catalog
Size
Price
LS-C408068-100
100 µg
$355

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Product Description

Cathepsin K antibody LS-C408068 is an unconjugated rabbit polyclonal antibody to human Cathepsin K (CTSK). Validated for IHC and WB.
About CTSK / Cathepsin K
CTSK / Cathepsin K is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. P43235 NM_000396 NP_000387.1

CTSK Antibody, Cathepsin K Antibody, Cathepsin K (pycnodysostosis) Antibody, Cathepsin O1 Antibody, Cathepsin O2 Antibody, Cathepsin X Antibody, CTSO2 Antibody, PKND Antibody, Procathepsin K Antibody, PYCD Antibody, Cathepsin O Antibody, CTS02 Antibody, CTSO1 Antibody


Specifications

Target
Human CTSK / Cathepsin K
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunogen affinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (0.5 - 1 µg/ml)
  • Western blot (0.1 - 0.5 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
E. coli-derived human Cathepsin K recombinant protein (Position: A115-M329). Human Cathepsin K shares 86.9% and 88.8% amino acid (aa) sequence identity with mouse and rat Cathepsin K, respectively.
Epitope
aa115-329
Specificity
Predominantly expressed in osteoclasts (bones).
Presentation
Lyophilized from 7.1 mM sodium phosphate, 77 mM NaCl, 2.5% BSA, 0.025% sodium azide
Reconstitution
Reconstitute with 200 µl of distilled water.
Storage
At -20°C for 1 year. After reconstitution, at 4°C for 1 month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid freeze-thaw cycles.
Restrictions
For research use only.

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Images

Immunohistochemistry

Cathepsin K was detected in paraffin-embedded sections of human osteosarcoma tissues using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method.
Cathepsin K was detected in paraffin-embedded sections of human osteosarcoma tissues using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method.

Western blot

Western blot analysis of Cathepsin K expression in HELA whole cell lysates (lane 1) and 22RV1 whole cell lysates (lane 2). Cathepsin K at 45 kD was detected using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.
Western blot analysis of Cathepsin K expression in HELA whole cell lysates (lane 1) and 22RV1 whole cell lysates (lane 2). Cathepsin K at 45 kD was detected using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.

Immunohistochemistry

Cathepsin K was detected in paraffin-embedded sections of human osteosarcoma tissues using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method.
Cathepsin K was detected in paraffin-embedded sections of human osteosarcoma tissues using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method.

Western blot

Western blot analysis of Cathepsin K expression in HELA whole cell lysates (lane 1) and 22RV1 whole cell lysates (lane 2). Cathepsin K at 45 kD was detected using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.
Western blot analysis of Cathepsin K expression in HELA whole cell lysates (lane 1) and 22RV1 whole cell lysates (lane 2). Cathepsin K at 45 kD was detected using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.

Immunohistochemistry

Cathepsin K was detected in paraffin-embedded sections of human osteosarcoma tissues using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method.
Cathepsin K was detected in paraffin-embedded sections of human osteosarcoma tissues using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method.

Western blot

Western blot analysis of Cathepsin K expression in HELA whole cell lysates (lane 1) and 22RV1 whole cell lysates (lane 2). Cathepsin K at 45 kD was detected using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.
Western blot analysis of Cathepsin K expression in HELA whole cell lysates (lane 1) and 22RV1 whole cell lysates (lane 2). Cathepsin K at 45 kD was detected using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.

Immunohistochemistry

Cathepsin K was detected in paraffin-embedded sections of human osteosarcoma tissues using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method.
Cathepsin K was detected in paraffin-embedded sections of human osteosarcoma tissues using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method.

Western blot

Western blot analysis of Cathepsin K expression in HELA whole cell lysates (lane 1) and 22RV1 whole cell lysates (lane 2). Cathepsin K at 45 kD was detected using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.
Western blot analysis of Cathepsin K expression in HELA whole cell lysates (lane 1) and 22RV1 whole cell lysates (lane 2). Cathepsin K at 45 kD was detected using rabbit anti- Cathepsin K Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.

Requested From: United States
Date Requested: 9/20/2018

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