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Catalog Number Size Price
LS-C21256-10 10 Blots $674 
Antibody

Polyclonal Rabbit anti‑Human CTNNB1 / Beta Catenin Antibody (phospho‑Ser45, WB) LS‑C21256

Polyclonal Rabbit anti‑Human CTNNB1 / Beta Catenin Antibody (phospho‑Ser45, WB) LS‑C21256

Antibody:
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (pSer45) Antibody
Application:
WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$674
LS-C21256-10
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (pSer45) Antibody
Application:
WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
Beta Catenin antibody LS-C21256 is an unconjugated rabbit polyclonal antibody to human Beta Catenin (CTNNB1) (pSer45). Validated for ELISA and WB.
Target
Human CTNNB1 / Beta Catenin
Synonyms
CTNNB1 | Beta-catenin | Catenin beta-1 | CTNNB | Beta Catenin
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic phosphopeptide derived from a region of human -catenin that contains serine 45. The sequence is conserved in mouse, rat and frog.
Epitope
pSer45
Specificity
Human -catenin. Mouse, rat and frog -catenin (100% homologous) have not been tested, but are expected to react.
Applications
  • Western blot (1:1000 - 1:2000)
  • ELISA
Usage
The antibody has been used for Western blotting applications. b-catenin (92kD) is a multifunctional protein involved in cell-cell adhesion, intracellular. signaling and gene transcription. b-catenin plays a key role in the Wnt pathway which mediates numerous developmental processes. Deregulation of the Wnt pathway results in the accumulation of b-catenin in the nucleus. Stabilizing mutations of several serine/threonine residues (more frequently of serine 45) have been found in multiple tumors. Phosphorylation of b-catenin on serine 45 by casein kinase I (CKI) primes its subsequent phosphorylation of residues 33, 37 and 41 by glycogen synthase-3b (GSK-3b) and results in its degradation. Applications: Suitable for use in ELISA, Western Blot. Western Blot: 1:1000-1:2000.
Presentation
1 mg/ml BSA (IgG, Protease free), PBS (without Mg2+, Ca2+), pH 7.2, 0.1% Sodium Azide, 50% Glycerol
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CTNNB1 / Beta Catenin
P35222 NM_001904 NP_001895.1

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 8/10/2022