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ERCC8 antibody LS-C30134 is an unconjugated rabbit polyclonal antibody to ERCC8 (CSA) from human, mouse, dog and other species. Validated for WB.
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Species:
Human, Mouse, Rat, Bovine
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Species:
Human, Mouse
Applications:
IHC, Western blot, ELISA
Species:
Human, Mouse
Applications:
IHC, Western blot, ELISA
Product Description
ERCC8 antibody LS-C30134 is an unconjugated rabbit polyclonal antibody to ERCC8 (CSA) from human, mouse, dog and other species. Validated for WB.
Specifications
Target
Human CSA / ERCC8
Synonyms
ERCC8, CKN1, UVSS2, CSA
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Dog, Rabbit, Zebrafish
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
- Western blot (0.2 - 1 µg/ml)
- (applications tested for the base form of this product only)
Immunogen
CSA / ERCC8 antibody was raised against synthetic peptide located between aa37-86 of human ERCC8 (Q13216, NP_000073). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Marmoset (100%); Zebra finch, Chicken (92%); Galago, Mouse, Hamster, Panda, Dog, Rabbit, Pig, Opossum, Zebrafish (84%).
Blocking Peptide
LS-E11235 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C30134. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Immunizing peptide used to generate LS-C30134. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa37-86
Specificity
Human ERCC8
Presentation
Lyophilized from PBS, 0.09% sodium azide, 2% sucrose
Reconstitution
Centrifuge the vial prior to opening. Reconstitute with sterile distilled water to a concentration of 1 mg/ml. Vortex and centrifuge again.
Storage
Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About CSA / ERCC8
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair.
Q13216
NM_000082
NP_000073.1
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Images
Western blot
Fetal Skeletal Muscle Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot
Fetal Skeletal Muscle Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot
Fetal Skeletal Muscle Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot
Fetal Skeletal Muscle Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Requested From: United States
Date Requested: 11/13/2018
Date Requested: 11/13/2018
