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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CSA / ERCC8 Antibody (aa37‑86) LS‑C30134
ERCC8 antibody LS-C30134 is an unconjugated rabbit polyclonal antibody to ERCC8 (CSA) from human, mouse, dog and other species. Validated for WB.
Catalog
Size
Price
LS-C30134-50
50 µg
$365

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Product Description

ERCC8 antibody LS-C30134 is an unconjugated rabbit polyclonal antibody to ERCC8 (CSA) from human, mouse, dog and other species. Validated for WB.

Specifications

Target
Human CSA / ERCC8
Synonyms
ERCC8, CKN1, UVSS2, CSA
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Dog, Rabbit, Zebrafish (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with Biotin, FITC, HRP.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (0.2 - 1 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
CSA / ERCC8 antibody was raised against synthetic peptide located between aa37-86 of human ERCC8 (Q13216, NP_000073). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Marmoset (100%); Zebra finch, Chicken (92%); Galago, Mouse, Hamster, Panda, Dog, Rabbit, Pig, Opossum, Zebrafish (84%).
Blocking Peptide
LS-E11235 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C30134. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa37-86
Specificity
Human ERCC8
Presentation
Lyophilized from PBS, 0.09% sodium azide, 2% sucrose
Reconstitution
Centrifuge the vial prior to opening. Reconstitute with sterile distilled water to a concentration of 1 mg/ml. Vortex and centrifuge again.
Storage
Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About CSA / ERCC8
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. Q13216 NM_000082 NP_000073.1


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Images

Western blot

Fetal Skeletal Muscle Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Fetal Skeletal Muscle Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Fetal Skeletal Muscle Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Fetal Skeletal Muscle Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Fetal Skeletal Muscle Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Fetal Skeletal Muscle Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Fetal Skeletal Muscle Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Fetal Skeletal Muscle Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Requested From: United States
Date Requested: 11/13/2018

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