(tested or 100% immunogen sequence identity)
Highly pure human ceruloplasmin.
Detects ceruloplasmin, a ~132kD metalloprotein that is secreted into the plasma by liver hepatocytes and activated monocytes/macrophages. Ceruloplasmin functions in copper transport, iron homeostasis, antioxidant defense, angiogenesis and coagulation. Deficiency in ceruloplasmin is termed aceruloplasminemia, an autosomal recessive disorder which leads to iron accumulation and tissue damage, in particular in the brain and visceral organs. Clinical features include retinal degeneration, diabetes mellitus and neurological disturbances. Elevated plasma ceruloplasmin has been shown to pose an increased risk in atherosclerosis and myocardial infarction.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
PBS, 0.01% Thimerosal, HRP stabilizer
Store at 4°C. Do not freeze.