COPS6 / CSN6

COP9 signalosome subunit 6

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets.

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Products

Antibodies (18)

Proteins (7)

Type

Over-Expression Lysate (2)

Primary (18)

Recombinant (5)

Target

COPS6 / CSN6 (25)

Reactivity

Human (18)

Mouse (4)

Rat (4)

Bat (3)

Bovine (3)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

Orangutan (3)

Pig (3)

Rabbit (3)

Xenopus (3)

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Application

IHC (9)

IHC-P (7)

WB (17)

ELISA (1)

ICC (1)

IF (4)

Host

rabbit (11)

mouse (7)

Product Group

IHCPlus (1)

Isotype

IgG (1)

IgG1 (4)

IgG2a (2)

IgG2a,k (1)

Clonality

monoclonal mc (7)

polyclonal pc (11)

Clone

2H5 (1)

OTI2F5 (2)

OTI2H4 (2)

OTI4E7 (2)

Format

Biotin Conjugated (2)

Carrier-free (3)

FITC Conjugated (2)

HRP Conjugated (2)

Unconjugated (12)

Epitope

C-Terminus (4)

aa201-250 (4)

aa58-327 (4)

Publications

No (24)

Yes (1)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-T7, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

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COPS6 / CSN6 Antibody (clone OTI4E7) LS-C174568

(4.0) Rating

(1) Publication(s)

Antibody:

COPS6 / CSN6 Mouse anti-Human Monoclonal (OTI4E7) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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COPS6 / CSN6 Antibody (aa58-327, clone OTI4E7, Carrier-free) LS-C787915

Antibody:

COPS6 / CSN6 Mouse anti-Human Monoclonal (aa58-327) (Carrier-free) (OTI4E7) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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COPS6 / CSN6 Antibody (aa201-250) LS-B12649

Antibody:

COPS6 / CSN6 Rabbit anti-Human Polyclonal (aa201-250) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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COPS6 / CSN6 Antibody (aa201-250, HRP) LS-C466170

Antibody:

COPS6 / CSN6 Rabbit anti-Human Polyclonal (aa201-250) (HRP) Antibody

Reactivity:

Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon, Orangutan

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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COPS6 / CSN6 Antibody (aa201-250, Biotin) LS-C466168

Antibody:

COPS6 / CSN6 Rabbit anti-Human Polyclonal (aa201-250) (Biotin) Antibody

Reactivity:

Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon, Orangutan

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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COPS6 / CSN6 Antibody (aa201-250, FITC) LS-C466169

Antibody:

COPS6 / CSN6 Rabbit anti-Human Polyclonal (aa201-250) (FITC) Antibody

Reactivity:

Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey, Gibbon, Orangutan

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

COPS6 / CSN6 Antibody LS-C668262

Antibody:

COPS6 / CSN6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

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COPS6 / CSN6 Antibody (clone 2H5) LS-C134034

Antibody:

COPS6 / CSN6 Mouse anti-Human Monoclonal (2H5) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

100 µg/$423

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COPS6 / CSN6 Antibody (clone OTI2F5) LS-C174502

Antibody:

COPS6 / CSN6 Mouse anti-Human Monoclonal (OTI2F5) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

COPS6 / CSN6 Antibody (aa58-327, clone OTI2F5, Carrier-free) LS-C797651

Antibody:

COPS6 / CSN6 Mouse anti-Human Monoclonal (aa58-327) (Carrier-free) (OTI2F5) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

COPS6 / CSN6 Antibody LS-C346213

Antibody:

COPS6 / CSN6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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COPS6 / CSN6 Antibody (aa58-327, clone OTI2H4) LS-C340612

Antibody:

COPS6 / CSN6 Mouse anti-Human Monoclonal (aa58-327) (OTI2H4) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

COPS6 / CSN6 Antibody (aa58-327, clone OTI2H4, Carrier-free) LS-C797653

Antibody:

COPS6 / CSN6 Mouse anti-Human Monoclonal (aa58-327) (Carrier-free) (OTI2H4) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

COPS6 / CSN6 Antibody LS-C343788

Antibody:

COPS6 / CSN6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$553

Select

COPS6 / CSN6 Antibody (C-Terminus) LS-C345570

Antibody:

COPS6 / CSN6 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

COPS6 / CSN6 Antibody (C-Terminus, HRP) LS-C466167

Antibody:

COPS6 / CSN6 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

COPS6 / CSN6 Antibody (C-Terminus, Biotin) LS-C466165

Antibody:

COPS6 / CSN6 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

COPS6 / CSN6 Antibody (C-Terminus, FITC) LS-C466166

Antibody:

COPS6 / CSN6 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

Human COPS6 / CSN6 Protein (Recombinant GST, N-terminus) (aa218-327) - LS-G61698

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human COPS6 / CSN6 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68257

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36 kDa

Price:

20 µg/$1,107

Select

Human COPS6 / CSN6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81762

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36 kDa

Price:

20 µg/$150

Select

Human COPS6 / CSN6 Protein (Recombinant GST) (Full Length) - LS-G32431

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

62.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human COPS6 / CSN6 Protein (Recombinant His-T7, N-terminus) (Met1-Ala260) - LS-G133312

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

32.7kDa

Price:

10 µg/$247; 50 µg/$303; 200 µg/$462; 100 µg/$370; 1 mg/$1,284; 500 µg/$922; 5 mg/$2,151; 2 mg/$1,437

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COPS6 / CSN6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115042

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36 kDa

Price:

100 µg/$494

Select

Human COPS6 / CSN6 Protein (Recombinant His) - LS-G2477

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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