COPS5 / JAB1

COP9 signalosome subunit 5

Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

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Products

Antibodies (41)

Proteins (4)

ELISA Kits (1)

Type

Cell-Based (1)

Over-Expression Lysate (2)

Primary (41)

Recombinant (2)

Target

COPS5 / JAB1 (46)

Reactivity

Human (42)

Mouse (31)

Rat (19)

Bat (3)

Bovine (1)

Chimpanzee (6)

Dog (4)

Fish (1)

Gibbon (3)

Guinea pig (6)

Horse (7)

Monkey (5)

Pig (8)

Rabbit (6)

Xenopus (1)

Zebrafish (2)

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Application

IHC (22)

IHC-P (15)

WB (40)

ELISA (4)

IF (8)

IP (10)

Peptide-ELISA (3)

Host

rabbit (29)

mouse (12)

Product Group

IHCPlus (5)

Isotype

IgG (19)

IgG1 (2)

IgG1,k (6)

IgG2a (2)

IgG2b (1)

Clonality

monoclonal mc (12)

polyclonal pc (29)

Clone

2A10.8 (1)

6C3.38 (1)

8H8.5 (1)

OTI2B12 (2)

Format

96-Well Microplate (1)

APC Conjugated (1)

Biotin Conjugated (3)

Carrier-free (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Preservative Free (2)

Unconjugated (30)

Epitope

N-Terminus (10)

Internal (2)

aa175-225 (2)

130-210 aa, Internal (1)

Lys191 (1)

aa1-334 (1)

aa161-210 (1)

aa187-222 (1)

aa8-334 (1)

Publications

No (46)

Sample Type

Adherent Cell Cultures (1)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

Select

IHC-plus™ COPS5 / JAB1 Antibody (clone 2A10.8) LS-B1689

(4.0) Rating

Antibody:

COPS5 / JAB1 Mouse anti-Mouse Monoclonal (2A10.8) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ COPS5 / JAB1 Antibody (clone 6C3.38, Preservative Free) LS-B1690

(4.0) Rating

Antibody:

COPS5 / JAB1 Mouse anti-Mouse Monoclonal (Preservative Free) (6C3.38) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated, Preservative Free

Price:

50 µl/$460

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COPS5 / JAB1 Antibody (N-Terminus) LS-C109598

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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IHC-plus™ COPS5 / JAB1 Antibody (N-Terminus) LS-B5185

(4.0) Rating

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

250 µl/$505

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IHC-plus™ COPS5 / JAB1 Antibody (clone 8H8.5, Preservative Free) LS-B4786

(4.0) Rating

Antibody:

COPS5 / JAB1 Mouse anti-Mouse Monoclonal (Preservative Free) (8H8.5) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated, Preservative Free

Price:

50 µl/$460

Select

IHC-plus™ COPS5 / JAB1 Antibody (Internal) LS-B2553

(4.0) Rating

Antibody:

COPS5 / JAB1 Mouse anti-Human Monoclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$485

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COPS5 / JAB1 Antibody (aa161-210) LS-C119190

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal (aa161-210) Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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COPS5 / JAB1 Antibody (clone OTI2B12) LS-C173771

Antibody:

COPS5 / JAB1 Mouse anti-Human Monoclonal (OTI2B12) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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COPS5 / JAB1 Antibody (clone OTI2B12, Carrier-free) LS-C786925

Antibody:

COPS5 / JAB1 Mouse anti-Human Monoclonal (Carrier-free) (OTI2B12) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

COPS5 / JAB1 Antibody LS-C335180

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

COPS5 / JAB1 Antibody LS-C809565

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

COPS5 / JAB1 Antibody (aa8-334) LS-C407703

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal (aa8-334) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

COPS5 / JAB1 Antibody LS-C490166

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

Select

COPS5 / JAB1 Antibody LS-C827140

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

COPS5 / JAB1 Antibody LS-C400839

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

COPS5 / JAB1 Antibody (130-210 aa, Internal) LS-C384203

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal (130-210 aa, Internal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

COPS5 / JAB1 Antibody (N-Terminus) LS-C190689

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Xenopus, Fish, Zebrafish, Pig, Horse, Mouse, Dog, Bovine, Rat, Human, Monkey

Applications:

IF, IP, WB

Format:

Unconjugated

Price:

100 µl/$688

Select

COPS5 / JAB1 Antibody (aa175-225) LS-C286958

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal (aa175-225) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

COPS5 / JAB1 Antibody (N-Terminus) LS-C29819

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$424

Select

COPS5 / JAB1 Antibody (Internal) LS-C353304

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Zebrafish, Pig, Mouse, Rat, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

COPS5 / JAB1 Antibody (Lys191) LS-C176942

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal (Lys191) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

COPS5 / JAB1 Antibody LS-C765731

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

COPS5 / JAB1 Antibody LS-C765732

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

COPS5 / JAB1 Antibody LS-C192959

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

COPS5 / JAB1 Antibody LS-C748453

Antibody:

COPS5 / JAB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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