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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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COPB2 / Beta‑COP Antibody (aa494‑511) IHC‑plus™ LS‑B2677
Note: This antibody replaces LS-C14587, LS-C14589
Beta-COP antibody LS-B2677 is an unconjugated rabbit polyclonal antibody to Beta-COP (COPB2) from human, mouse, rat and other species. Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-B2677-50
50 µg (1 mg/ml)
$425

Popular COPB2 / Beta-COP Products

COPB2 Antibody western blot of mouse stomach tissue lysates (35 ug/lane). The COPB2 antibody detected the COPB2 protein (arrow).
Species: Human, Mouse
Applications: Western blot
Immunohistochemistry of paraffin-embedded mouse brain tissue.
Species: Human, Mouse, Rat
Applications: IHC, Immunofluorescence, Western blot
Immunohistochemistry of paraffin-embedded human spleen tissue at dilution 1:100
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA
Antibody
Species: Human, Mouse, Rat
Applications: IHC, Immunofluorescence, Western blot

Product Description

Beta-COP antibody LS-B2677 is an unconjugated rabbit polyclonal antibody to Beta-COP (COPB2) from human, mouse, rat and other species. Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues.

Specifications

Target
Rat COPB2 / Beta-COP
Synonyms
COPB2, Betaprime-COP, Beta'-COP, Beta-coat protein, Beta-COP, p102, Coatomer beta' subunit, Coatomer subunit beta
Host
Rabbit
Reactivity
Rat, Human, Monkey, Mouse, Bat, Bovine, Dog, Horse, Pig (tested or 100% immunogen sequence identity)
Predicted
Rabbit (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • Western blot (2 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic peptide: KVLAAQETHEGVTEDGIE, corresponding to amino acids 494-511 of Rat beta COP I. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Panda, Dog, Bat, Bovine, Horse, Pig, Opossum, Platypus (100%); Orangutan, Rabbit, Lizard (94%); Chicken (89%); Turkey, Xenopus, Sea anemone (83%).
Epitope
aa494-511
Specificity
Detects rat coatomer-protein I beta (COP I beta).
Usage
Immunohistochemistry: LS-B2677 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2677 was determined to be 5 ug/ml. Western Blot: 2 ug/ml; Detects an ~115kD protein representing COP I beta from PC-12 cell extract.
Presentation
PBS, 1 mg/ml BSA, 0.05% Sodium Azide
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.
About COPB2 / Beta-COP
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. P35606 NM_004766 NP_004757.1


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Images

Immunohistochemistry

Anti-COPB2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.
Anti-COPB2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.

Immunohistochemistry

Anti-COPB2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.
Anti-COPB2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.

Immunohistochemistry

Anti-COPB2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.
Anti-COPB2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.

Immunohistochemistry

Anti-COPB2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.
Anti-COPB2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.

Immunohistochemistry

Anti-COPB2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.
Anti-COPB2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.

Immunohistochemistry

Anti-COPB2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.
Anti-COPB2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.

Immunohistochemistry

Anti-COPB2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.
Anti-COPB2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.

Immunohistochemistry

Anti-COPB2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.
Anti-COPB2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2677 concentration 5 ug/ml.

Requested From: United States
Date Requested: 10/21/2018

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