Complement C5 antibody LS-C41851 is an unconjugated sheep polyclonal antibody to human Complement C5. Validated for ID and IHC.
Human Complement C5
(tested or 100% immunogen sequence identity)
Ion exchange chromatography
- IHC - Paraffin (1:100)
See our complete line of Immunohistochemistry Reagents
including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Complement C5 antibody was raised against human C5, purified from plasma.
Recognizes complement component 5 (C5), a member of the complement system. The complement system consists of a tightly regulated network of proteins. Its activation leads to a sequential cascade of enzymatic reactions, resulting in opsonisation of the pathogens and their removal by phagocytes, as well as cell lysis. Three pathways have been described, the antibody-dependent pathway (classical pathway), the alternative pathway and the lectin activation pathway. The complement system plays a critical role in both innate and adaptive immune responses. It is also involved in tissue regeneration, tumor growth and some human pathologies. Complement component 5 is the initiator of the effector terminal phase of the complement system. C5 convertase cleaves C5 into C5a, a potent anaphylatoxin, and C5b, ultimately resulting in the formation of the multimeric membrane attack complex (MAC) together with the other components of the terminal pathway (C5b-C9). Gives a single arc when tested by immunoelectrophoresis (IEP) against human plasma. The identity has been confirmed by double diffusion against fresh human plasma and a known anti human C5.
Saline, pH 7.4, Glycine, 1 mM EDTA, 0.1% EACA, 0.09% Sodium Azide, 0.01% Benzamidine
For research use only.