Human Complement C5

Sheep

Human (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Ion exchange chromatography

Unmodified

Human C5, purified from plasma.

Recognizes complement component 5 (C5), a member of the complement system. The complement system consists of a tightly regulated network of proteins. Its activation leads to a sequential cascade of enzymatic reactions, resulting in opsonisation of the pathogens and their removal by phagocytes, as well as cell lysis. Three pathways have been described, the antibody-dependent pathway (classical pathway), the alternative pathway and the lectin activation pathway. The complement system plays a critical role in both innate and adaptive immune responses. It is also involved in tissue regeneration, tumor growth and some human pathologies. Complement component 5 is the initiator of the effector terminal phase of the complement system. C5 convertase cleaves C5 into C5a, a potent anaphylatoxin, and C5b, ultimately resulting in the formation of the multimeric membrane attack complex (MAC) together with the other components of the terminal pathway (C5b-C9). Gives a single arc when tested by immunoelectrophoresis (IEP) against human plasma. The identity has been confirmed by double diffusion against fresh human plasma and a known anti human C5.

• IHC - Paraffin (1:100)
• Immunodiffusion

GBS, 1 mM EDTA, 0.1% EACA, 0.09% Sodium Azide, 0.01% Benzamidine

Store at 4°C or at -20°C. Store undiluted. Avoid freeze/thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P01031 NCBI: NM_001735 NP_001726.2