Complement C5

complement component 5

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

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Antibodies (54)

ELISA Kits (28)

Proteins (12)

Type

Competitive EIA (1)

Custom (3)

Over-Expression Lysate (2)

Primary (53)

Recombinant (10)

Sandwich (24)

Secondary (1)

Target

Complement C5 (94)

Reactivity

Human (48)

Mouse (23)

Rat (9)

Chicken (1)

Guinea pig (1)

Monkey (2)

Pig (1)

Porcine (1)

Sheep (1)

Application

IHC (13)

IHC-Fr (1)

IHC-P (7)

WB (44)

Flo (1)

ELISA (22)

ID (2)

Neut (1)

Peptide-ELISA (1)

Host

rabbit (23)

mouse (26)

goat (3)

sheep (2)

Product Group

IHCPlus (2)

Isotype

IgG (15)

IgG1 (7)

IgG2a (3)

IgG2a,k (8)

IgG2b,k (8)

Clonality

monoclonal mc (26)

polyclonal pc (28)

Clone

046-10.2.2 (10-04) (1)

2942 (1)

557 (1)

561 (1)

HCC 5.1 (1)

HCC5.1 (1)

Format

96-Well Microplate (4)

96-Well Strip Plate (24)

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aa253-281 (7)

aa678-751 (4)

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aa1-77 (1)

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aa59-77 (1)

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No (94)

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Cell Culture Supernatants (3)

Plasma (24)

Serum (24)

Tissue Homogenates (5)

Tag

6His, N-terminus (1)

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His, N-Terminal (2)

His-SUMO (1)

Myc-DDK (Flag) (2)

Species

Human (8)

Mouse (3)

Rat (1)

Source

293T Cells (1)

E. coli (7)

HEK 293 Cells (1)

Human (1)

Mammalian Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (4)

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Complement C5 Antibody (aa1-18) LS-C313394

Antibody:

Complement C5 Rabbit anti-Rat Polyclonal (aa1-18) Antibody

Reactivity:

Mouse, Rat

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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Complement C5 Antibody (aa1-77) LS-C344039

Antibody:

Complement C5 Rabbit anti-Rat Polyclonal (aa1-77) Antibody

Reactivity:

Rat

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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Complement C5 Antibody (clone 557) LS-C14521

Antibody:

Complement C5 Mouse anti-Human Monoclonal (557) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$752

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Complement C5 Antibody LS-C22314

Antibody:

Complement C5 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$862

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Complement C5 Antibody (aa253-281) LS-C168151

Antibody:

Complement C5 Rabbit anti-Human Polyclonal (aa253-281) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Mouse Complement C5 (Sandwich ELISA) ELISA Kit - LS-F24781

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$669

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Mouse Complement C5 (Sandwich ELISA) ELISA Kit - LS-F21340

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human Complement C5 (Sandwich ELISA) ELISA Kit - LS-F24462

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$717

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Human Complement C5 (Sandwich ELISA) ELISA Kit - LS-F5788

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

3.12 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$798

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Rat Complement C5 (Sandwich ELISA) ELISA Kit - LS-F5840

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$856

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Complement C5 Antibody LS-B15694

Antibody:

Complement C5 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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Complement C5 Antibody (clone HCC5.1) LS-C22315

Antibody:

Complement C5 Mouse anti-Human Monoclonal (HCC5.1) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

50 µg/$891

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Complement C5 Antibody (clone 2942) LS-C22319

Antibody:

Complement C5 Mouse anti-Human Monoclonal (2942) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$826

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Complement C5 Antibody (N-Terminus, clone 046-10.2.2 (10-04)) LS-C44979

Antibody:

Complement C5 Mouse anti-Human Monoclonal (N-Terminus) (046-10.2.2 (10-04)) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$536

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Complement C5 Antibody LS-C409639

Antibody:

Complement C5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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Rat Complement C5 (Sandwich ELISA) ELISA Kit - LS-F34563

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse Complement C5 (Sandwich ELISA) ELISA Kit - LS-F6286

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

12.5 - 800 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$818

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IHC-plus™ Complement C5 Antibody LS-B15730

(4.0) Rating

Antibody:

Complement C5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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Complement C5 Antibody (aa1223-1451) LS-C186223

Antibody:

Complement C5 Rabbit anti-Human Polyclonal (aa1223-1451) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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Complement C5 Antibody (N-Terminus, clone 561) LS-C14520

Antibody:

Complement C5 Mouse anti-Human Monoclonal (N-Terminus) (561) Antibody

Reactivity:

Human

Applications:

ELISA, Neut

Format:

Unconjugated

Price:

100 µg/$752

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Complement C5 Antibody LS-C809743

Antibody:

Complement C5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Complement C5 Antibody LS-C140221

Antibody:

Complement C5 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$589

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Complement C5 Antibody (FITC) LS-C147223

Antibody:

Complement C5 Goat anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

IHC

Format:

FITC Conjugated

Price:

1 ml/$438

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Human Complement C5 Protein (Recombinant) (aa678-751) - LS-G55945

Source:

Human

Tag:

None

Price:

50 µg/$842; 10 µg/$345; 200 µg/$1,480; 100 µg/$1,258; 1 mg/$2,788; 500 µg/$2,284; 5 mg/$5,881; 2 mg/$3,137

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Pig Complement C5 (Sandwich ELISA) ELISA Kit - LS-F18924

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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