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Catalog Number Size Price
LS-C22305-50 50 µg $747 
Antibody

Monoclonal Mouse anti‑Human Complement C3 Antibody (clone H13, IHC, WB) LS‑C22305

Monoclonal Mouse anti‑Human Complement C3 Antibody (clone H13, IHC, WB) LS‑C22305

Note: This antibody replaces LS-C22292, LS-C123298
Antibody:
Complement C3 Mouse anti-Human Monoclonal (H13) Antibody
Application:
IHC, IHC-Fr, WB
Reactivity:
Human, Guinea pig, Rabbit
Format:
Unconjugated, Unmodified
Price
Catalog Number
$747
LS-C22305-50
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
Complement C3 Mouse anti-Human Monoclonal (H13) Antibody
Application:
IHC, IHC-Fr, WB
Reactivity:
Human, Guinea pig, Rabbit
Format:
Unconjugated, Unmodified

Specifications

Description
Complement C3 antibody LS-C22305 is an unconjugated mouse monoclonal antibody to Complement C3 from human. It is reactive with human, guinea pig and rabbit. Validated for IHC and WB.
Target
Human Complement C3
Synonyms
C3 | AHUS5 | ARMD9 | Complement component C3 | CPAMD1 | Complement C3 | ASP | Complement component 3
Host
Mouse
Reactivity
Human, Guinea pig, Rabbit (tested or 100% immunogen sequence identity)
Clonality
IgG2b Monoclonal
Clone
H13
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Immunogen
Human complement component C3.
Specificity
Recognizes a C3a-determinant (C3 alpha-chain) which is present also on native C3. Allows discrimination of ubiquitous or nonspecifically bound native C3 from biologically active C3b fragment, C3b or C are negative with this clone. The antibody inhibits the anaphylactic function of C3a: the capacity of C3a to induce serotonin release from thrombocytes in vitro is inhibited; similarly, treatment of C3a with the antibody inhibits the C3a-induced skin reaction in vivo. Species cross-reactivity: Guinea pig and rabbit C3/C3a.
Applications
  • IHC
  • IHC - Frozen
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Suitable for use in Immunohistochemistry (frozen sections) and Western blotting. The antibody is, in combination with antibodies to the C3b fragment, an excellent control for distinguishing ubiquitous or nonspecifically bound native C3 from the biologically active C3 fragment. Nonactivated C3 still bears the C3a determinant, whereas activated C3 (C3b, C3d) is C3a-negative. It is therefore useful for immunopathological assays (demonstration of C3 deposition in biopsies) and for C3a assays research purposes.
Presentation
Lyophilized from PBS, pH 7.4, 0.5% BSA, 0.9% sodium azide
Reconstitution
Reconstitute with 1.0 ml sterile ddH2O
Storage
Lyophilized and resuspended forms: store at -20°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About Complement C3
P01024 NM_000064 NP_000055.2

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 8/14/2022