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CNGB1
cyclic nucleotide gated channel beta 1
Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit.
| Gene Name: | cyclic nucleotide gated channel beta 1 |
| Family/Subfamily: | Ion Channel , Cyclic nucleotide gated channel |
| Synonyms: | CNGB1, CNG channel 4, CNCG2, CNCG4, CNG-4, CNG4. 1, CNG4. 3, CNCG3L, CNG channel beta-1, CNG4, GARP, Glutamic acid-rich protein 1, Glutamic acid-rich protein, Glutamic-acid-rich protein, RCNC2, RCNCbeta, RP45, CNGB1B, RCNCb |
| Target Sequences: | NM_001297 NP_001288.3 Q14028 |
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