Human CLEC7A / Dectin 1
CLEC7A | BGR | CANDF4 | CLECSF12 | Dectin-1 | DC-associated C-type lectin 1 | DECTIN1 | HDectin-1 | Beta-glucan receptor | Lectin-like receptor 1 | CD369
(tested or 100% immunogen sequence identity)
NIH3T3 cells expressing full length Beta-glucan receptor.
Recognizes human Dectin-1, also known as beta-glucan receptor (GR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (GR-A and GR-B) and several minor isoforms. GR-A and GR-B differs by the presence and absence, respectively, of a stalk region. The antibody (clone GE2) recognizes both of these isoforms. Clone GE2 could be used to inhibit receptor function.