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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CLDN1 / Claudin 1 Antibody LS‑C498623
Claudin 1 antibody LS-C498623 is an unconjugated rabbit polyclonal antibody to human Claudin 1 (CLDN1). Validated for ELISA, IF and IHC.
Catalog
Size
Price
LS-C498623-50
50 µg
$285
LS-C498623-100
100 µg
$385
Description
Claudin 1 antibody LS-C498623 is an unconjugated rabbit polyclonal antibody to human Claudin 1 (CLDN1). Validated for ELISA, IF and IHC.
Target
Human CLDN1 / Claudin 1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with FITC, HRP, Biotin.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • Immunofluorescence
  • ELISA
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Recombinant human Claudin-1 protein (24-161AA)
Specificity
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only.
About CLDN1 / Claudin 1
O95832 NM_021101 NP_066924.1

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Images

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human liver tissue using CLDN1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver tissue using CLDN1 Antibody at dilution of 1:100

Immunofluorescence

Immunofluorescent analysis of HepG2 cells using CLDN1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of HepG2 cells using CLDN1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human liver tissue using CLDN1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver tissue using CLDN1 Antibody at dilution of 1:100

Immunofluorescence

Immunofluorescent analysis of HepG2 cells using CLDN1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of HepG2 cells using CLDN1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human liver tissue using CLDN1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver tissue using CLDN1 Antibody at dilution of 1:100

Immunofluorescence

Immunofluorescent analysis of HepG2 cells using CLDN1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of HepG2 cells using CLDN1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human liver tissue using CLDN1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver tissue using CLDN1 Antibody at dilution of 1:100

Immunofluorescence

Immunofluorescent analysis of HepG2 cells using CLDN1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of HepG2 cells using CLDN1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Requested From: United States
Date Requested: 12/18/2018
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