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CLCF1

cardiotrophin-like cytokine factor 1

CLCF1 is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Name: cardiotrophin-like cytokine factor 1
Synonyms: CLCF1, B-cell stimulating factor 3, BSF-3, BSF3, CISS2, NR6, Novel neurotrophin-1, NNT1, B-cell stimulatory factor 3, B-cell-stimulating factor 3, NNT-1, BCSF-3
Target Sequences: NM_013246 NP_037378.1 Q9UBD9

Publications (2)

1
Fc?RIIb on B Cells and Myeloid Cells Modulates B Cell Activation and Autoantibody Responses via Different but Synergistic Pathways in Lupus-Prone Yaa Mice. Lin Q, Ohtsuji M, Amano H, Tsurui H, Tada N, Sato R, Fukuyama H, Nishimura H, Verbeek JS, Hirose S. Journal of immunology (Baltimore, Md. : 1950). 2018 December;201:3199-3210. [Full Text Article] [PubMed:30373853]
2
Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases. Gökhan Cildir, John Toubia, Kwok Ho Yip, Mingyan Zhou, Harshita Pant, Pravin Hissaria, Jingxian Zhang, Wanjin Hong, Nirmal Robinson, Michele A Grimbaldeston, Angel F Lopez, Vinay Tergaonkar. Immunity. 2019 November;51:949-965.e6. [Full Text Article] [PubMed:31653482]

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CLCF1 Protein - Recombinant Cardiotrophin Like Cytokine Factor 1 By SDS-PAGE
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E. coli
His, N-Terminal
26.2 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
CLCF1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
3.12 - 200 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$854
CLCF1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$834
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CLCF1 Rabbit anti-Mouse Polyclonal (aa28-225) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
CLCF1 Antibody - Western blot of recombinant CLCF1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLCF1 Rabbit anti-Mouse Polyclonal (aa28-225) (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
CLCF1 Antibody - Western blot of recombinant CLCF1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLCF1 Rabbit anti-Mouse Polyclonal (aa28-225) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
CLCF1 Antibody - Western blot of recombinant CLCF1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLCF1 Rabbit anti-Mouse Polyclonal (aa28-225) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
CLCF1 Antibody - Western blot of recombinant CLCF1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLCF1 Rabbit anti-Mouse Polyclonal (aa28-225) (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
CLCF1 Antibody - Western blot of recombinant CLCF1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLCF1 Rabbit anti-Mouse Polyclonal (aa28-225) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
CLCF1 Antibody - Anti-CLCF1 antibody IHC of human lung, macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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CLCF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
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CLCF1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
CLCF1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
23.5 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$870
CLCF1 ELISA Kit
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Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CLCF1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
100 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
CLCF1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CLCF1 Antibody - Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200.
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CLCF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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CLCF1 Rabbit anti-Human Polyclonal (aa46-72) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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CLCF1 Rabbit anti-Human Polyclonal (aa46-72) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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CLCF1 Rabbit anti-Human Polyclonal (aa46-72) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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CLCF1 Rabbit anti-Human Polyclonal (aa46-72) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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CLCF1 Rabbit anti-Human Polyclonal (aa46-72) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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CLCF1 Rabbit anti-Human Polyclonal (aa46-72) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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CLCF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC-P
Unconjugated
100 µg/$357
CLCF1 Antibody - CLCF1 Antibody western blot of A549 cell line lysates (35 ug/lane). The CLCF1 antibody detected the CLCF1 protein (arrow).
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CLCF1 Rabbit anti-Human Polyclonal (aa46-72) Antibody
Human
WB
Unconjugated
400 µl/$393
CLCF1 Antibody - Western blot of recombinant CLCF1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLCF1 Rabbit anti-Human Polyclonal (aa88-190) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
Viewing 1-25 of 63 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).