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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ClC‑5 / CLCN5 Antibody (aa521‑570) LS‑C135021
CLCN5 antibody LS-C135021 is an unconjugated rabbit polyclonal antibody to CLCN5 (ClC-5) from human, mouse, rat and other species. Validated for WB.
Catalog
Size
Price
LS-C135021-50
50 µg
$365

Popular ClC-5 / CLCN5 Products

Antibody
Species: Rat, Human
Applications: Western blot, ELISA
CLCN5 Antibody western blot of K562 cell line lysates (35 ug/lane). The CLCN5 antibody detected the CLCN5 protein (arrow).
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Species: Human, Mouse
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Antibody
Species: Human, Mouse, Rat
Applications: IHC, Western blot

Product Description

CLCN5 antibody LS-C135021 is an unconjugated rabbit polyclonal antibody to CLCN5 (ClC-5) from human, mouse, rat and other species. Validated for WB.
About ClC-5 / CLCN5
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. P51795 NM_000084 NP_000075.1

CLCN5 Antibody, DENTS Antibody, CLC5 Antibody, HCIC-K2 Antibody, Nephrolithiasis 1 (X-linked) Antibody, Nephrolithiasis 2, X-linked Antibody, NPHL1 Antibody, NPHL2 Antibody, XLRH Antibody, XRN Antibody, Chloride channel 5 Antibody, Chloride channel protein 5 Antibody, Chloride transporter ClC-5 Antibody, ClC-5 Antibody, CLCK2 Antibody, HClC-K2 Antibody


Specifications

Target
Mouse ClC-5 / CLCN5
Host
Rabbit
Reactivity
Mouse, Human, Rat, Bovine, Dog, Guinea pig, Horse, Rabbit, Sheep (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with Biotin, FITC, HRP.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (0.2 - 1 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
ClC-5 / CLCN5 antibody was raised against synthetic peptide located between aa521-570 of mouse Clcn5 (Q9WVD4, NP_057900). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Galago, Marmoset, Mouse, Rat, Sheep, Elephant, Dog, Bovine, Rabbit, Horse, Guinea pig (100%); Opossum, Turkey, Zebra finch, Chicken, Platypus, Xenopus, Zebrafish, Drosophila (92%); Stickleback (85%); Hamster (84%).
Blocking Peptide
LS-E12437 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C135021. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa521-570
Specificity
Mouse CLCN5 / CLC5
Usage
Western Blot: Suggested dilution at 1 ug/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.
Presentation
Lyophilized from PBS, 0.09% sodium azide, 2% sucrose
Reconstitution
Centrifuge the vial prior to opening. Reconstitute with sterile distilled water to a concentration of 1 mg/ml. Vortex and centrifuge again.
Storage
Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images

Western blot

CLCN5 / CLC5 antibody LS-C135021 Western blot of Mouse Brain lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CLCN5 / CLC5 antibody LS-C135021 Western blot of Mouse Brain lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

CLCN5 / CLC5 antibody LS-C135021 Western blot of Mouse Brain lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CLCN5 / CLC5 antibody LS-C135021 Western blot of Mouse Brain lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

CLCN5 / CLC5 antibody LS-C135021 Western blot of Mouse Brain lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CLCN5 / CLC5 antibody LS-C135021 Western blot of Mouse Brain lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

CLCN5 / CLC5 antibody LS-C135021 Western blot of Mouse Brain lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CLCN5 / CLC5 antibody LS-C135021 Western blot of Mouse Brain lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Requested From: United States
Date Requested: 8/15/2018

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